Document Detail

Stroke prevention and statin treatment.
MedLine Citation:
PMID:  16833043     Owner:  NLM     Status:  MEDLINE    
Randomized trials with statins have shown a modest but significant absolute reduction in the incidence of stroke in patients with a previous myocardial infarction. The reasons for the positive statin effect on stroke endpoint are unclear, because a link between serum cholesterol level and stroke never has been established. However, positive results of statin trials were mainly obtained in patients with an average or a low serum cholesterol level. Statins have a good overall safety profile. Statins reduced stroke incidence in high-risk (mainly coronary heart disease, diabetics, and hypertensives) population even with a normal baseline blood cholesterol level. In patients with prior strokes, statins reduce the incidence of coronary events, but it is not yet proven if drugs of this class actually reduce the incidence of recurrent strokes in terms of secondary prevention.
Lucilla Parnetti; Valeria Caso; Alessia Lanari; Emanuele Saggese; Michela Sebastianelli; Seyed Khosrow Tayebati; Francesco Amenta
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Clinical and experimental hypertension (New York, N.Y. : 1993)     Volume:  28     ISSN:  1064-1963     ISO Abbreviation:  Clin. Exp. Hypertens.     Publication Date:    2006 Apr-May
Date Detail:
Created Date:  2006-07-12     Completed Date:  2006-07-27     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9305929     Medline TA:  Clin Exp Hypertens     Country:  United States    
Other Details:
Languages:  eng     Pagination:  335-44     Citation Subset:  IM    
Department of Neuroscience, University of Perugia, Perugia, Italy.
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MeSH Terms
Clinical Trials as Topic
Hydroxymethylglutaryl-CoA Reductase Inhibitors / therapeutic use*
Hyperlipidemias / complications,  drug therapy
Stroke / epidemiology,  etiology,  prevention & control*
Survival Rate
Treatment Outcome
Reg. No./Substance:
0/Hydroxymethylglutaryl-CoA Reductase Inhibitors

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