Document Detail

Stroke prevention: is it possible? If so, which antihypertensive agent should be used?
MedLine Citation:
PMID:  13678484     Owner:  NLM     Status:  MEDLINE    
The importance of blood pressure control in stroke prevention is supported by a large body of clinical evidence. However, it is not known which antihypertensive agents are most effective in preventing stroke. As stroke is characterised by vascular remodelling and dysfunction and by effects on the cerebral circulation, selecting an agent that has a direct vascular protective effect beyond blood pressure control may be desirable. Results with the angiotensin receptor blockers (ARBs) in clinical trials (LIFE and SCOPE) support the findings in animal models that ARBs may be a promising therapeutic option for prevention of stroke and possibly, cognitive decline.
Shokei Kim
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current medical research and opinion     Volume:  19     ISSN:  0300-7995     ISO Abbreviation:  Curr Med Res Opin     Publication Date:  2003  
Date Detail:
Created Date:  2003-09-18     Completed Date:  2004-03-24     Revised Date:  2013-05-28    
Medline Journal Info:
Nlm Unique ID:  0351014     Medline TA:  Curr Med Res Opin     Country:  England    
Other Details:
Languages:  eng     Pagination:  442-4     Citation Subset:  IM    
Department of Pharmacology, Osaka City University Graduate School of Medicine, Osaka, Japan.
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MeSH Terms
Angiotensin Receptor Antagonists*
Antihypertensive Agents / pharmacology,  therapeutic use*
Benzimidazoles / pharmacology,  therapeutic use*
Cerebrovascular Circulation / drug effects
Hypertension / prevention & control
Losartan / pharmacology,  therapeutic use*
Rats, Inbred SHR
Stroke / prevention & control*
Tetrazoles / pharmacology,  therapeutic use*
Reg. No./Substance:
0/Angiotensin Receptor Antagonists; 0/Antihypertensive Agents; 0/Benzimidazoles; 0/Tetrazoles; 114798-26-4/Losartan; S8Q36MD2XX/candesartan

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