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Stroke prevention in atrial fibrillation.
MedLine Citation:
PMID:  22193836     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Atrial Fibrillation (AF) is a common arrhythmia associated with substantial morbidity and mortality, particularly due to thromboembolic strokes, the prevalence of which is expected to rise over the next few decades. This article reviews the complex mechanisms behind thromboembolism, compares the newer risk stratification models for identifying those at risk for stroke or bleeding, and highlights the potential advantages and disadvantages of available therapies. Newer oral anticoagulants like Dabigatran, Rivoroxaban, and Apixiban are discussed. There is also discussion on non pharmacological therapies such as left atrial appendage ligation and occlusion devices. This article is intended to help clinicians gain a better understanding of available risk stratification tools and therapies available for prevention of stroke in patients with atrial fibrillation.
Authors:
Ilyas Mohammed; Adam Mohmand-Borkowski; James F Burke; Peter R Kowey
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-12-21
Journal Detail:
Title:  Journal of cardiovascular medicine (Hagerstown, Md.)     Volume:  -     ISSN:  1558-2035     ISO Abbreviation:  -     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2011-12-23     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101259752     Medline TA:  J Cardiovasc Med (Hagerstown)     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
aLankenau Hospital and Institute for Medical Research Center, Wynnewood, Pennsylvania bCleveland Clinic Foundation, Cleveland, Ohio, USA.
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