Document Detail

Stroke precipitated by moderate blood pressure reduction.
MedLine Citation:
PMID:  11074327     Owner:  NLM     Status:  MEDLINE    
Rapid lowering of blood pressure can precipitate or worsen ischemic strokes. This usually has been observed in the setting of profoundly lowered pressure and hypotension. We report on six patients in whom ischemic neurologic injury ensued or worsened after moderate reduction of blood pressure by pharmacological treatment. The 6 patients suffered new or worsened ischemic neurologic deficits after receiving oral or intravenous antihypertensive medications, mostly after relatively small doses. Mean arterial blood pressure in these patients was decreased by 25 +/- 7.7%, or 37 +/- 16 mm Hg (mean +/- SD) without resultant hypotension. These cases emphasize the potential hazards of moderate blood pressure reduction by antihypertensive medications in the setting of an acute ischemic stroke or transient ischemic attack (TIA), as well as rapidly treated hypertension even in those who have not yet manifested ischemic symptoms.
G M Fischberg; E Lozano; K Rajamani; S Ameriso; M J Fisher
Related Documents :
14963377 - Predictors of early neurological deterioration after ischaemic stroke: a case-control s...
17705177 - Management of blood pressure after acute ischemic stroke: an evidence-based guide for t...
3732297 - Central haemodynamics in acute myocardial infarction in relation to mortality and peak ...
19641277 - The role of ras modification for primary and secondary stroke prevention.
16647977 - Pulmonary arterial pressure in children with croup syndrome.
1119707 - Cardiovascular responses to calcium administered intravenously to man during halothane ...
Publication Detail:
Type:  Case Reports; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of emergency medicine     Volume:  19     ISSN:  0736-4679     ISO Abbreviation:  J Emerg Med     Publication Date:  2000 Nov 
Date Detail:
Created Date:  2000-11-29     Completed Date:  2000-12-14     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8412174     Medline TA:  J Emerg Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  339-46     Citation Subset:  IM    
University of Southern California, Los Angeles, California, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Antihypertensive Agents / adverse effects*
Blood Pressure / drug effects
Emergency Treatment / adverse effects,  methods
Felodipine / adverse effects
Hypertension / complications*,  drug therapy*
Labetalol / adverse effects
Magnetic Resonance Angiography
Magnetic Resonance Imaging
Middle Aged
Nifedipine / adverse effects
Patient Selection
Precipitating Factors
Stroke / chemically induced*,  diagnosis
Tomography, X-Ray Computed
Grant Support
Reg. No./Substance:
0/Antihypertensive Agents; 21829-25-4/Nifedipine; 36894-69-6/Labetalol; 72509-76-3/Felodipine
Comment In:
J Emerg Med. 2001 Oct;21(3):290-1   [PMID:  11604289 ]
J Emerg Med. 2000 Nov;19(4):379   [PMID:  11074336 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Acute thoracoabdominal aortic dissection presenting as painless, transient paralysis of the lower ex...
Next Document:  Massive hemoperitoneum due to rupture of a retroperitoneal varix.