| Stroke precipitated by moderate blood pressure reduction. | |
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MedLine Citation:
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PMID: 11074327 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Rapid lowering of blood pressure can precipitate or worsen ischemic strokes. This usually has been observed in the setting of profoundly lowered pressure and hypotension. We report on six patients in whom ischemic neurologic injury ensued or worsened after moderate reduction of blood pressure by pharmacological treatment. The 6 patients suffered new or worsened ischemic neurologic deficits after receiving oral or intravenous antihypertensive medications, mostly after relatively small doses. Mean arterial blood pressure in these patients was decreased by 25 +/- 7.7%, or 37 +/- 16 mm Hg (mean +/- SD) without resultant hypotension. These cases emphasize the potential hazards of moderate blood pressure reduction by antihypertensive medications in the setting of an acute ischemic stroke or transient ischemic attack (TIA), as well as rapidly treated hypertension even in those who have not yet manifested ischemic symptoms. |
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Authors:
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G M Fischberg; E Lozano; K Rajamani; S Ameriso; M J Fisher |
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Publication Detail:
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Type: Case Reports; Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The Journal of emergency medicine Volume: 19 ISSN: 0736-4679 ISO Abbreviation: J Emerg Med Publication Date: 2000 Nov |
Date Detail:
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Created Date: 2000-11-29 Completed Date: 2000-12-14 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8412174 Medline TA: J Emerg Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 339-46 Citation Subset: IM |
Affiliation:
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University of Southern California, Los Angeles, California, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Antihypertensive Agents / adverse effects* Blood Pressure / drug effects Emergency Treatment / adverse effects, methods Felodipine / adverse effects Female Humans Hypertension / complications*, drug therapy* Labetalol / adverse effects Magnetic Resonance Angiography Magnetic Resonance Imaging Male Middle Aged Nifedipine / adverse effects Patient Selection Precipitating Factors Stroke / chemically induced*, diagnosis Tomography, X-Ray Computed |
| Grant Support | |
ID/Acronym/Agency:
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NS 31945/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Antihypertensive Agents; 21829-25-4/Nifedipine; 36894-69-6/Labetalol; 72509-76-3/Felodipine |
| Comments/Corrections | |
Comment In:
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J Emerg Med. 2001 Oct;21(3):290-1
[PMID:
11604289
]
J Emerg Med. 2000 Nov;19(4):379 [PMID: 11074336 ] |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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