Document Detail

Stroke in systemic lupus erythematosus.
MedLine Citation:
PMID:  2237945     Owner:  NLM     Status:  MEDLINE    
We investigated the clinical and pathologic characteristics of stroke in 234 patients with systemic lupus erythematosus. Thirteen patients (5.6%) developed cerebrovascular disease. Cerebral infarction was noted in eight, cerebral hemorrhage in two, and subarachnoid hemorrhage in three. In seven (54%) of these 13 patients, stroke occurred less than or equal to 5 years after systemic lupus erythematosus was diagnosed. Among the predisposing risk factors for stroke, hypertension was the most important. Lupus anticoagulant was detected in three (38%) and anticardiolipin antibody in three (43% of seven investigated) of the patients with infarction. Evaluation of the clinical manifestations and autoantibodies indicated that renal involvement and high titers of anti-deoxyribonucleic acid antibody were more frequent in the stroke group than in the non-stroke group. Autopsy studies on six of the patients with stroke revealed small infarcts and hemorrhages in all, but in no case was true angiitis observed. Libman-Sacks endocarditis was found in two of the three patients with infarction. In conclusion, the important contributory factor to the development of stroke in patients with systemic lupus erythematosus is considered to be hypertension mediated by immunologic abnormalities. Antiphospholipid antibodies and Libman-Sacks endocarditis are closely associated with occlusive cerebrovascular disease.
Y Kitagawa; F Gotoh; A Koto; H Okayasu
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Publication Detail:
Type:  Case Reports; Comparative Study; Journal Article    
Journal Detail:
Title:  Stroke; a journal of cerebral circulation     Volume:  21     ISSN:  0039-2499     ISO Abbreviation:  Stroke     Publication Date:  1990 Nov 
Date Detail:
Created Date:  1990-12-24     Completed Date:  1990-12-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0235266     Medline TA:  Stroke     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1533-9     Citation Subset:  IM    
Department of Neurology, Kawasaki Municipal Hospital, Japan.
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MeSH Terms
Cardiolipins / immunology
Cerebral Infarction / complications,  pathology
Cerebrovascular Disorders / etiology*,  pathology,  radiography
Endocarditis / pathology
Enzyme-Linked Immunosorbent Assay
Hypertension / complications
Lupus Erythematosus, Systemic / complications*,  immunology
Middle Aged
Partial Thromboplastin Time
Risk Factors
Time Factors
Tomography, X-Ray Computed
Reg. No./Substance:
Erratum In:
Stroke 1991 Mar;22(3):417

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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