Document Detail


Stroke in a multiple myeloma patient treated with thalidomide.
MedLine Citation:
PMID:  17904089     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
The antiangiogenic and immunomodulatory properties of thalidomide have led to its use and evaluation in refractory or relapsed multiple myeloma (MM). However, thalidomide use is associated with several side effects, although deep vein thrombosis and peripheral neuropathy are the most serious. The incidence of thrombosis after treatment with thalidomide ranges from 2% to 23%, but is higher among patients who also receive chemotherapy. Thromboembolic episodes are usually venous and may cause pulmonary embolism or even myocardial infarction and cerebral venous thrombosis. Arterial occlusion is rare, and the association between arterial thrombotic events and thalidomide is infrequent with only a few patients reported who developed arterial strokes on thalidomide. We describe a case of nonfatal thrombotic stroke occurring in a patient with relapsed MM treated with thalidomide.
Authors:
Xavier Ortín; Marta Rodríguez-Luaces; Marisa Calabuig; Llorenç Font
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association     Volume:  15     ISSN:  1532-8511     ISO Abbreviation:  J Stroke Cerebrovasc Dis     Publication Date:    2006 Nov-Dec
Date Detail:
Created Date:  2007-10-01     Completed Date:  2008-07-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9111633     Medline TA:  J Stroke Cerebrovasc Dis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  283-5     Citation Subset:  -    
Affiliation:
Servicio de Hematología, Hospital de Tortosa Verge de la Cinta, Tortosa, Spain.
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