| Stroke in early childhood due to homocystinuria. | |
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MedLine Citation:
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PMID: 20837312 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A previously healthy girl, age 3 years 9 months, presented with right-sided hemiparesis and seizures. Ischemic infarction was confirmed through magnetic resonance imaging and magnetic resonance angiography. Extensive evaluation to discover the underlying etiologies and risk factors predisposing this patient to stroke included coagulation defects, cardiac anomalies, congenital inborn metabolism deficiency, and infections and trauma. Based on the clinical and laboratory results, a diagnosis of homocystinuria was made. Homocystinuria is an inherited disorder that affects the metabolism of the amino acid methionine. Although homocystinuria is usually associated with ischemic strokes, the sudden onset of stroke as the initial clinical presentation of homocystinuria is very rare in early childhood. Based on this case, however, metabolic screening for hyperhomocystinemia is recommended in any child presenting with a stroke. |
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Authors:
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Füsun Alehan; Semra Saygi; Sansal Gedik; Esra Meltem Kayahan Ulu |
Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Pediatric neurology Volume: 43 ISSN: 1873-5150 ISO Abbreviation: Pediatr. Neurol. Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-09-14 Completed Date: 2011-01-21 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8508183 Medline TA: Pediatr Neurol Country: United States |
Other Details:
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Languages: eng Pagination: 294-6 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier Inc. All rights reserved. |
Affiliation:
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Division of Child Neurology, Baskent University Faculty of Medicine, Ankara, Turkey. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Brain Ischemia
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etiology,
pathology Cerebral Angiography Child, Preschool Female Homocystinuria / complications*, pathology Humans Magnetic Resonance Imaging Paresis / etiology*, pathology Seizures / etiology*, pathology Stroke / etiology*, pathology |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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