Document Detail

Stroke is associated with coronary calcification as detected by electron-beam CT: the Rotterdam Coronary Calcification Study.
MedLine Citation:
PMID:  11823653     Owner:  NLM     Status:  MEDLINE    
BACKGROUND AND PURPOSE: Coronary calcification as detected by electron-beam CT measures the atherosclerotic plaque burden and has been reported to predict coronary events. Because atherosclerosis is a generalized process, coronary calcification may also be associated with manifest atherosclerotic disease at other sites of the vascular tree. We examined whether coronary calcification as detected by electron-beam CT is related to the presence of stroke. METHODS: From 1997 onward, subjects were invited to participate in the prospective Rotterdam Coronary Calcification Study and undergo electron-beam CT to detect coronary calcification. The study was embedded in the population-based Rotterdam Study. Calcifications were quantified in a calcium score according to Agatston's method. Calcium scores were available for 2013 subjects (mean age [SD], 71 [5.7] years). Fifty subjects had experienced stroke before scanning. RESULTS: Subjects were 2 times more likely to have experienced stroke when their calcium score was between 101 and 500 (odds ratio [OR], 2.1; 95% CI, 0.9 to 4.7) and 3 times more likely when their calcium score was above 500 (OR, 3.3; 95% CI, 1.5 to 7.2), compared with subjects in the lowest calcium score category (0 to 100). Additional adjustment for cardiovascular risk factors did not materially alter the risk estimates. CONCLUSIONS: In this population-based study, a markedly graded association was found between coronary calcification and stroke. The results suggest that coronary calcification as detected by electron-beam CT may be useful to identify subjects at high risk of stroke.
Rozemarijn Vliegenthart; Monika Hollander; Monique M B Breteler; Deirdre A M van der Kuip; Albert Hofman; Matthijs Oudkerk; Jacqueline C M Witteman
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Stroke; a journal of cerebral circulation     Volume:  33     ISSN:  1524-4628     ISO Abbreviation:  Stroke     Publication Date:  2002 Feb 
Date Detail:
Created Date:  2002-02-01     Completed Date:  2002-02-21     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0235266     Medline TA:  Stroke     Country:  United States    
Other Details:
Languages:  eng     Pagination:  462-5     Citation Subset:  IM    
Department of Epidemiology & Biostatistics, Erasmus Medical Center Rotterdam, Rotterdam, The Netherlands.
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MeSH Terms
Aged, 80 and over
Calcinosis / epidemiology*,  radiography
Cohort Studies
Coronary Artery Disease / epidemiology*,  radiography
Follow-Up Studies
Logistic Models
Middle Aged
Netherlands / epidemiology
Odds Ratio
Predictive Value of Tests
Risk Assessment
Risk Factors
Severity of Illness Index
Stroke / diagnosis,  epidemiology*
Tomography, X-Ray Computed*
Comment In:
Stroke. 2002 Oct;33(10):2345-6; author reply 2345-6   [PMID:  12364716 ]

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