Document Detail


Stroke location and brain function in an embolic rabbit stroke model.
MedLine Citation:
PMID:  20417119     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: Current rabbit stroke models often depend on symptoms as endpoints for embolization and produce wide variation in location, size, and severity of strokes. In a further refinement of an angiographic embolic stroke model, localized infarctions were correlated to neurologic deficits with the goal to create a rabbit model for long-term studies of therapies after stroke.
MATERIALS AND METHODS: New Zealand White rabbits (4-5 kg; N = 71) had selective internal carotid artery (ICA) angiography and a single clot was injected. At 24 hours, neurologic assessment score (NAS) was measured on an 11-point scale (0, normal; 10, dead). Brains were removed and stained to identify stroke areas. All animals with single strokes (n = 31) were analyzed by specific brain structure involvement, and NAS values were correlated.
RESULTS: Stroke incidence differed by location, with cortex, subcortical, and basal ganglia regions highest. The middle cerebral artery (MCA), at 52%, and anterior cerebral artery (ACA), at 29%, were most commonly involved, with the largest stroke volumes in the ACA distribution. Brainstem and cerebellum strokes had disproportionately severe neurologic deficits, scoring 2.25 +/- 1.0 on the NAS, which represented a significant (P < .02) difference versus cortex (0.5 +/- 0.2), subcortical (1.3 +/- 0.4), and basal ganglia (0.5 +/- 0.3), all in the frontal or parietal regions.
CONCLUSIONS: MCA and ACA distributions included 81% of strokes. These sites were relatively silent (potentially allowing longer-term survival studies) whereas others in the posterior circulation produced disproportionately severe symptoms. Symptoms were not reliable indicators of stroke occurrence, and other endpoints such as imaging may be required. These are important steps toward refinement of the rabbit stroke model.
Authors:
Aliza T Brown; Robert D Skinner; Rene Flores; Leah Hennings; Michael J Borrelli; John Lowery; William C Culp
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2010-04-22
Journal Detail:
Title:  Journal of vascular and interventional radiology : JVIR     Volume:  21     ISSN:  1535-7732     ISO Abbreviation:  J Vasc Interv Radiol     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-05-24     Completed Date:  2010-09-28     Revised Date:  2014-09-18    
Medline Journal Info:
Nlm Unique ID:  9203369     Medline TA:  J Vasc Interv Radiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  903-9     Citation Subset:  IM    
Copyright Information:
Copyright (c) 2010 SIR. Published by Elsevier Inc. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Animals
Brain / physiopathology*,  radiography*
Disease Models, Animal*
Humans
Intracranial Embolism / etiology,  physiopathology*,  radiography*
Rabbits
Stroke / etiology,  physiopathology*,  radiography*
Grant Support
ID/Acronym/Agency:
R01 HL082481/HL/NHLBI NIH HHS; R01 HL082481-01/HL/NHLBI NIH HHS; R01 HL082481-02/HL/NHLBI NIH HHS; R01 HL082481-03/HL/NHLBI NIH HHS; R01 HL082481-04/HL/NHLBI NIH HHS; R01 HL082481-05/HL/NHLBI NIH HHS; R01HL82481/HL/NHLBI NIH HHS
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