Document Detail


Strict red blood cell transfusion guideline reduces the need for transfusions in very-low-birthweight infants in the first 4 weeks of life: a multicentre trial.
MedLine Citation:
PMID:  15720608     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND AND OBJECTIVES: Very-low-birthweight infants are among the most heavily transfused patients. The objective of this study was to verify if the introduction of a strict guideline would reduce the need for red blood cell transfusions in the first 4 weeks of life in these neonates. MATERIALS AND METHODS: This was a multicentre prospective study of two cohorts of very-low-birthweight infants transfused in accordance with the recommendations of a neonatologist (Phase 1) or according to previously published guidelines (Phase 2). RESULTS: In the first 28 days of life, 102 patients (68.5%) in Phase 1 and 117 (59.7%) in Phase 2 were transfused. The number of transfusions was 1.9 +/- 2.0 in Phase 1 and 1.4 +/- 1.6 in Phase 2 (P = 0.01). After adjusting for gestational age, blood loss and the presence of respiratory distress syndrome, the strict guideline reduced the number of transfusions in 17.6% (IC 95%-30.5% to -2.6%). CONCLUSIONS: The strict guideline was effective in reducing erythrocyte transfusions in very-low-birthweight infants.
Authors:
A M Miyashiro; N dos Santos; R Guinsburg; B I Kopelman; C de Araújo Peres; M F de Lima Taga; A R Shinzato; H de Paula Fiod Costa
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Publication Detail:
Type:  Clinical Trial; Journal Article; Multicenter Study    
Journal Detail:
Title:  Vox sanguinis     Volume:  88     ISSN:  0042-9007     ISO Abbreviation:  Vox Sang.     Publication Date:  2005 Feb 
Date Detail:
Created Date:  2005-02-21     Completed Date:  2005-07-21     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0413606     Medline TA:  Vox Sang     Country:  England    
Other Details:
Languages:  eng     Pagination:  107-13     Citation Subset:  IM    
Affiliation:
Department of Pediatrics, Division of Neonatal Medicine, Federal University of São Paulo, São Paulo, Brazil. ameliamiyashiro@yahoo.com.br
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MeSH Terms
Descriptor/Qualifier:
Blood Volume
Cohort Studies
Erythrocyte Transfusion / utilization*
Gestational Age
Hematocrit
Hemoglobins / analysis
Hospitalization
Humans
Infant, Newborn
Infant, Very Low Birth Weight / blood*
Practice Guidelines as Topic*
Premature Birth / blood
Chemical
Reg. No./Substance:
0/Hemoglobins

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