| Striatum-dependent habits are insensitive to both increases and decreases in reinforcer value in mice. | |
| | |
MedLine Citation:
|
PMID: 23298231 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
The mouse has emerged as an advantageous species for studying the brain circuitry that underlies complex behavior and for modeling neuropsychiatric disease. The transition from flexible, goal-directed actions to inflexible, habitual responses is argued to be a valid and reliable behavioral model for studying a core aspect of corticostriatal systems that is implicated in certain forms of psychopathology. This transition is thought to correspond to a progression of behavioral control from associative to sensorimotor corticobasal ganglia networks. Habits form following extensive training and are characterized by reduced sensitivity of instrumental responding to reinforcer revaluation; few studies have examined this form of behavioral control in mice. Here we examined the involvement of the dorsolateral and dorsomedial striatum in this transition in the C57BL/6 inbred mouse strain. We provided evidence that damage to the dorsolateral striatum disrupted habitual responding, i.e. it preserved sensitivity to changes in outcome value following either outcome devaluation or, shown for the first time in mice, outcome inflation. Together, these data show that instrumental responding in lesioned mice tracks the current value of a reinforcer and provide evidence that neuroanatomical mechanisms underlying habit learning in rats are preserved in the mouse. This will allow for the genetic and molecular dissection of neural factors involved in decision-making and mechanisms of aberrant habit formation. |
| | |
Authors:
|
Jennifer J Quinn; Christopher Pittenger; Anni S Lee; Jamie L Pierson; Jane R Taylor |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2013-1-9 |
Journal Detail:
|
Title: The European journal of neuroscience Volume: - ISSN: 1460-9568 ISO Abbreviation: Eur. J. Neurosci. Publication Date: 2013 Jan |
Date Detail:
|
Created Date: 2013-1-9 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8918110 Medline TA: Eur J Neurosci Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
© 2013 Federation of European Neuroscience Societies and Blackwell Publishing Ltd. |
Affiliation:
|
Department of Psychology, Miami University, 90 N. Patterson Avenue, Oxford, OH, 45056, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Proteomic comparison of historic and recently emerged hypervirulent Clostridium difficile strains.
Next Document: Cancer-Associated Fibroblast and M2 Macrophage markers together predict outcome in Colorectal Cancer...