Document Detail


Striatum-dependent habits are insensitive to both increases and decreases in reinforcer value in mice.
MedLine Citation:
PMID:  23298231     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The mouse has emerged as an advantageous species for studying the brain circuitry that underlies complex behavior and for modeling neuropsychiatric disease. The transition from flexible, goal-directed actions to inflexible, habitual responses is argued to be a valid and reliable behavioral model for studying a core aspect of corticostriatal systems that is implicated in certain forms of psychopathology. This transition is thought to correspond to a progression of behavioral control from associative to sensorimotor corticobasal ganglia networks. Habits form following extensive training and are characterized by reduced sensitivity of instrumental responding to reinforcer revaluation; few studies have examined this form of behavioral control in mice. Here we examined the involvement of the dorsolateral and dorsomedial striatum in this transition in the C57BL/6 inbred mouse strain. We provided evidence that damage to the dorsolateral striatum disrupted habitual responding, i.e. it preserved sensitivity to changes in outcome value following either outcome devaluation or, shown for the first time in mice, outcome inflation. Together, these data show that instrumental responding in lesioned mice tracks the current value of a reinforcer and provide evidence that neuroanatomical mechanisms underlying habit learning in rats are preserved in the mouse. This will allow for the genetic and molecular dissection of neural factors involved in decision-making and mechanisms of aberrant habit formation.
Authors:
Jennifer J Quinn; Christopher Pittenger; Anni S Lee; Jamie L Pierson; Jane R Taylor
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2013-01-09
Journal Detail:
Title:  The European journal of neuroscience     Volume:  37     ISSN:  1460-9568     ISO Abbreviation:  Eur. J. Neurosci.     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-03-19     Completed Date:  2013-08-29     Revised Date:  2014-03-07    
Medline Journal Info:
Nlm Unique ID:  8918110     Medline TA:  Eur J Neurosci     Country:  France    
Other Details:
Languages:  eng     Pagination:  1012-21     Citation Subset:  IM    
Copyright Information:
© 2013 Federation of European Neuroscience Societies and Blackwell Publishing Ltd.
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MeSH Terms
Descriptor/Qualifier:
Animals
Conditioning, Operant
Corpus Striatum / anatomy & histology,  physiology*
Habits*
Habituation, Psychophysiologic
Mice
Mice, Inbred C57BL
Reinforcement (Psychology)*
Grant Support
ID/Acronym/Agency:
AA017776/AA/NIAAA NIH HHS; DA011717/DA/NIDA NIH HHS; DA027844/DA/NIDA NIH HHS; K08 MH081190/MH/NIMH NIH HHS; K08MH081190/MH/NIMH NIH HHS; MH066172/MH/NIMH NIH HHS; P20 DA027844/DA/NIDA NIH HHS; R01 DA011717/DA/NIDA NIH HHS; R03 AA017776/AA/NIAAA NIH HHS; UL1-AA017537/AA/NIAAA NIH HHS
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