Document Detail

Striatal muscarinic receptor antagonism reduces 24-h food intake in association with decreased preproenkephalin gene expression.
MedLine Citation:
PMID:  16367789     Owner:  NLM     Status:  MEDLINE    
Cholinergic interneurons of the striatum respond to motivationally relevant stimuli and are involved in appetitive learning. However, there has been relatively little inquiry into the role of striatal acetylcholine in food motivation. Here we show in rats that a single infusion of the muscarinic receptor antagonist scopolamine (0, 5.0 or 10.0 microg/0.5 microL bilaterally) potently reduced 24-h food intake following injections into either the ventral or dorsal striatum, without affecting water intake. Furthermore, muscarinic receptor blockade induced reliable and widespread reductions in striatal preproenkephalin, but not preprodynorphin, mRNA expression. These data suggest a novel role for striatal acetylcholine in modulating feeding behavior via its effects on enkephalin gene expression. As prior research indicates a critical role for striatal enkephalin in consummatory behaviors and palatability, we hypothesize that cholinergic interneurons assist in translating hypothalamic energy state signals into food-directed behaviors via their regulation of striatal opioid peptides.
Wayne E Pratt; Ann E Kelley
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  The European journal of neuroscience     Volume:  22     ISSN:  0953-816X     ISO Abbreviation:  Eur. J. Neurosci.     Publication Date:  2005 Dec 
Date Detail:
Created Date:  2005-12-21     Completed Date:  2006-03-02     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8918110     Medline TA:  Eur J Neurosci     Country:  France    
Other Details:
Languages:  eng     Pagination:  3229-40     Citation Subset:  IM    
Department of Psychiatry, University of Wisconsin-Madison, 6001 Research Park Boulevard, Madison, WI 53719, USA.
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MeSH Terms
Behavior, Animal / drug effects
Body Weight / drug effects
Corpus Striatum / anatomy & histology,  drug effects*,  physiology
Dose-Response Relationship, Drug
Drug Administration Schedule
Eating / drug effects*,  physiology
Enkephalins / genetics,  metabolism*
Gene Expression / drug effects*
In Situ Hybridization / methods
Locomotion / drug effects
Muscarinic Antagonists / pharmacology*
Nerve Tissue Proteins / genetics,  metabolism
Protein Precursors / genetics,  metabolism*
Rats, Sprague-Dawley
Scopolamine / pharmacology*
Time Factors
Grant Support
Reg. No./Substance:
0/Enkephalins; 0/Muscarinic Antagonists; 0/Nerve Tissue Proteins; 0/Protein Precursors; 0/cocaine- and amphetamine-regulated transcript protein; 51-34-3/Scopolamine; 93443-35-7/preproenkephalin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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