| Striatal dopamine transporter levels correlate with apathy in neurodegenerative diseases A SPECT study with partial volume effect correction. | |
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MedLine Citation:
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PMID: 17900799 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: The aim of the present study was to stress the relationship between neuropsychiatric symptoms and most particularly apathy and striatal dopamine uptake in patients with Alzheimer's disease (AD) or dementia with Lewy body (DLB). PATIENTS AND METHODS: Twenty-two patients (AD n=14; DLB n=8) were included. All patients had neuropsychological and behavioral examination including Mini Mental Test Examination (MMSE), Neuropsychiatric Inventory (NPI), and UPDRS for the motor activity assessment. Apathy dimensions, emotional blunting, lack of initiative and lack of interest were assessed using the Apathy Inventory (AI). Dopamine transporter (DAT) striatal uptake was assessed using (123)I-FP-CIT (DaTSCAN) SPECT. Quantitative measurements were obtained in 3D using a method which compensates for physical detection biases including partial volume effect. RESULTS: We observed a correlation between DAT uptake and NPI's domains only for apathy. More specifically using the AI, lack of initiative significantly correlated with bilateral putamen DAT uptake. Using partial correlation coefficients controlling for the UPDRS score, the correlation remained significant between lack of initiative and right and left putamen DAT uptake. CONCLUSION: These results demonstrate a relationship between apathy and DAT levels independent from motor activity. They suggest that the patients with neurodegenerative diseases presenting with apathy are characterized by some degree of dopaminergic neuronal loss. |
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Authors:
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Renaud David; Malick Koulibaly; Michel Benoit; René Garcia; Hervé Caci; Jacques Darcourt; Philippe Robert |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2007-09-27 |
Journal Detail:
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Title: Clinical neurology and neurosurgery Volume: 110 ISSN: 0303-8467 ISO Abbreviation: Clin Neurol Neurosurg Publication Date: 2008 Jan |
Date Detail:
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Created Date: 2007-12-24 Completed Date: 2008-04-17 Revised Date: 2009-10-14 |
Medline Journal Info:
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Nlm Unique ID: 7502039 Medline TA: Clin Neurol Neurosurg Country: Netherlands |
Other Details:
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Languages: eng Pagination: 19-24 Citation Subset: IM |
Affiliation:
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Centre Mémoire de Ressource et de Recherche, CHU Nice, France. vadner@hotmail.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Alzheimer Disease / metabolism*, psychology, radionuclide imaging Cerebral Cortex / metabolism*, radionuclide imaging Dopamine Plasma Membrane Transport Proteins / metabolism* Female Humans Image Processing, Computer-Assisted Lewy Body Disease / metabolism*, psychology, radionuclide imaging Male Neuropsychological Tests Tomography, Emission-Computed, Single-Photon |
| Chemical | |
Reg. No./Substance:
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0/Dopamine Plasma Membrane Transport Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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