Document Detail


Striatal dopamine transporter levels correlate with apathy in neurodegenerative diseases A SPECT study with partial volume effect correction.
MedLine Citation:
PMID:  17900799     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: The aim of the present study was to stress the relationship between neuropsychiatric symptoms and most particularly apathy and striatal dopamine uptake in patients with Alzheimer's disease (AD) or dementia with Lewy body (DLB). PATIENTS AND METHODS: Twenty-two patients (AD n=14; DLB n=8) were included. All patients had neuropsychological and behavioral examination including Mini Mental Test Examination (MMSE), Neuropsychiatric Inventory (NPI), and UPDRS for the motor activity assessment. Apathy dimensions, emotional blunting, lack of initiative and lack of interest were assessed using the Apathy Inventory (AI). Dopamine transporter (DAT) striatal uptake was assessed using (123)I-FP-CIT (DaTSCAN) SPECT. Quantitative measurements were obtained in 3D using a method which compensates for physical detection biases including partial volume effect. RESULTS: We observed a correlation between DAT uptake and NPI's domains only for apathy. More specifically using the AI, lack of initiative significantly correlated with bilateral putamen DAT uptake. Using partial correlation coefficients controlling for the UPDRS score, the correlation remained significant between lack of initiative and right and left putamen DAT uptake. CONCLUSION: These results demonstrate a relationship between apathy and DAT levels independent from motor activity. They suggest that the patients with neurodegenerative diseases presenting with apathy are characterized by some degree of dopaminergic neuronal loss.
Authors:
Renaud David; Malick Koulibaly; Michel Benoit; René Garcia; Hervé Caci; Jacques Darcourt; Philippe Robert
Related Documents :
1531069 - Comparison of same-day protocols using technetium-99m-sestamibi myocardial imaging.
10149589 - The diagnostic and prognostic value of exercise electrocardiography in asymptomatic sub...
17701169 - Chronic exertional compartment syndrome of the lower extremities: improved screening us...
6707369 - The pacing stress test: thallium-201 myocardial imaging after atrial pacing. diagnostic...
3264019 - Normal spect thallium-201 bull's-eye display: gender differences.
12701859 - The normal optic nerve head on heidelberg retina tomograph ii.
17918549 - Effects of a computer feedback treatment and behavioral support protocol on drop out fr...
20364349 - Impact of exercise training on oxidative stress in individuals with a spinal cord injury.
16283369 - Adaptation of left ventricular morphology to long-term training in sprint- and enduranc...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-09-27
Journal Detail:
Title:  Clinical neurology and neurosurgery     Volume:  110     ISSN:  0303-8467     ISO Abbreviation:  Clin Neurol Neurosurg     Publication Date:  2008 Jan 
Date Detail:
Created Date:  2007-12-24     Completed Date:  2008-04-17     Revised Date:  2009-10-14    
Medline Journal Info:
Nlm Unique ID:  7502039     Medline TA:  Clin Neurol Neurosurg     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  19-24     Citation Subset:  IM    
Affiliation:
Centre Mémoire de Ressource et de Recherche, CHU Nice, France. vadner@hotmail.com
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Aged
Aged, 80 and over
Alzheimer Disease / metabolism*,  psychology,  radionuclide imaging
Cerebral Cortex / metabolism*,  radionuclide imaging
Dopamine Plasma Membrane Transport Proteins / metabolism*
Female
Humans
Image Processing, Computer-Assisted
Lewy Body Disease / metabolism*,  psychology,  radionuclide imaging
Male
Neuropsychological Tests
Tomography, Emission-Computed, Single-Photon
Chemical
Reg. No./Substance:
0/Dopamine Plasma Membrane Transport Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Diagnostic criteria, classification, and nomenclature for painful bladder syndrome/interstitial cyst...
Next Document:  Genetic variant of the human homologous recombination-associated gene RMI1 (S455N) impacts the risk ...