Document Detail

Striatal dopamine transporter levels correlate with apathy in neurodegenerative diseases A SPECT study with partial volume effect correction.
MedLine Citation:
PMID:  17900799     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: The aim of the present study was to stress the relationship between neuropsychiatric symptoms and most particularly apathy and striatal dopamine uptake in patients with Alzheimer's disease (AD) or dementia with Lewy body (DLB). PATIENTS AND METHODS: Twenty-two patients (AD n=14; DLB n=8) were included. All patients had neuropsychological and behavioral examination including Mini Mental Test Examination (MMSE), Neuropsychiatric Inventory (NPI), and UPDRS for the motor activity assessment. Apathy dimensions, emotional blunting, lack of initiative and lack of interest were assessed using the Apathy Inventory (AI). Dopamine transporter (DAT) striatal uptake was assessed using (123)I-FP-CIT (DaTSCAN) SPECT. Quantitative measurements were obtained in 3D using a method which compensates for physical detection biases including partial volume effect. RESULTS: We observed a correlation between DAT uptake and NPI's domains only for apathy. More specifically using the AI, lack of initiative significantly correlated with bilateral putamen DAT uptake. Using partial correlation coefficients controlling for the UPDRS score, the correlation remained significant between lack of initiative and right and left putamen DAT uptake. CONCLUSION: These results demonstrate a relationship between apathy and DAT levels independent from motor activity. They suggest that the patients with neurodegenerative diseases presenting with apathy are characterized by some degree of dopaminergic neuronal loss.
Renaud David; Malick Koulibaly; Michel Benoit; René Garcia; Hervé Caci; Jacques Darcourt; Philippe Robert
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-09-27
Journal Detail:
Title:  Clinical neurology and neurosurgery     Volume:  110     ISSN:  0303-8467     ISO Abbreviation:  Clin Neurol Neurosurg     Publication Date:  2008 Jan 
Date Detail:
Created Date:  2007-12-24     Completed Date:  2008-04-17     Revised Date:  2009-10-14    
Medline Journal Info:
Nlm Unique ID:  7502039     Medline TA:  Clin Neurol Neurosurg     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  19-24     Citation Subset:  IM    
Centre Mémoire de Ressource et de Recherche, CHU Nice, France.
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MeSH Terms
Aged, 80 and over
Alzheimer Disease / metabolism*,  psychology,  radionuclide imaging
Cerebral Cortex / metabolism*,  radionuclide imaging
Dopamine Plasma Membrane Transport Proteins / metabolism*
Image Processing, Computer-Assisted
Lewy Body Disease / metabolism*,  psychology,  radionuclide imaging
Neuropsychological Tests
Tomography, Emission-Computed, Single-Photon
Reg. No./Substance:
0/Dopamine Plasma Membrane Transport Proteins

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