Document Detail


Striatal dopamine release stimulated by amphetamine or potassium: influence of ovarian hormones and the light-dark cycle.
MedLine Citation:
PMID:  6488037     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The release of endogenous dopamine (DA) from rat striatal tissue was studied in an in vitro superfusion system following hormonal manipulations in vivo. Progesterone treatment in estrogen-primed ovariectomized female rats potentiated DA release stimulated either by amphetamine or potassium (K+). In addition, the amount of striatal DA released in response to K+-stimulation was influenced by the light-dark cycle. We conclude that striatal DA release is modulated by ovarian hormones, and suggest that ovarian hormone modulation of presynaptic striatal DA activity may contribute to well-known estrous cycle dependent variations in some non-reproductive behaviors.
Authors:
J B Becker; M E Beer; T E Robinson
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Brain research     Volume:  311     ISSN:  0006-8993     ISO Abbreviation:  Brain Res.     Publication Date:  1984 Oct 
Date Detail:
Created Date:  1984-12-19     Completed Date:  1984-12-19     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0045503     Medline TA:  Brain Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  157-60     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Castration
Circadian Rhythm / drug effects*
Corpus Striatum / drug effects,  secretion*
Darkness
Dextroamphetamine / pharmacology*
Dopamine / secretion*
Estradiol / pharmacology*
Female
Light
Potassium / pharmacology*
Progesterone / pharmacology*
Rats
Grant Support
ID/Acronym/Agency:
HD05997/HD/NICHD NIH HHS; NS16437/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
50-28-2/Estradiol; 51-64-9/Dextroamphetamine; 57-83-0/Progesterone; 7440-09-7/Potassium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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