Document Detail


Striatal dopamine release in vitro from immature male rats shows enhanced responsiveness to pulsatile, but not continuous, infusions of L-dopa.
MedLine Citation:
PMID:  1769106     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In the present experiment we compared the effects of continuous versus pulsed infusions of L-beta-3,4,dihydroxyphenylalanine (L-DOPA) upon dopamine and 3,4-dihydroxyphenylacetic acid (DOPAC) release in vitro from superfused corpus striatal tissue fragments of immature (25-32 day) and adult (90-120 day) male rats. In response to two pulse infusions of L-DOPA (5 microM) a significantly greater amount of dopamine and DOPAC was released from the striatal fragments of immature vs adult males. In contrast, when L-DOPA was infused continuously throughout the superfusion virtually identical amounts of dopamine and DOPAC were obtained for immature and adult male rats. No differences in postsuperfusion dopamine tissue content were obtained between adult and immature rats following the two pulses or continuous infusion of L-DOPA. These results suggest that the corpus striatum of the immature rat has an enhanced capacity to convert and release dopamine in response to a submaximal pulsatile infusion of L-DOPA.
Authors:
D Dluzen; J McDermott
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Brain research. Developmental brain research     Volume:  62     ISSN:  0165-3806     ISO Abbreviation:  Brain Res. Dev. Brain Res.     Publication Date:  1991 Oct 
Date Detail:
Created Date:  1992-02-26     Completed Date:  1992-02-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8908639     Medline TA:  Brain Res Dev Brain Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  273-6     Citation Subset:  IM    
Affiliation:
Department of Anatomy, Northeastern Ohio Universities, College of Medicine Rootstown 44272-9989.
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MeSH Terms
Descriptor/Qualifier:
3,4-Dihydroxyphenylacetic Acid / metabolism
Aging / metabolism*
Animals
Corpus Striatum / metabolism*
Dopamine / metabolism*
Levodopa / administration & dosage*,  pharmacology
Male
Pulsatile Flow
Rats
Rats, Inbred Strains
Chemical
Reg. No./Substance:
0/Levodopa; 102-32-9/3,4-Dihydroxyphenylacetic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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