Document Detail


Striatal dopamine function in a family with multiple SCA-3 phenotypes.
MedLine Citation:
PMID:  20809346     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
We present single photon emission computed tomography (SPECT) studies using 123IFP-CIT (DAT scan) and 123I-IBZM imaging, performed on four members of a family with genetically proven spinocerebellar ataxia type 3 (SCA-3). DAT scan showed significant asymmetric decreased binding in the striatum in the two members with predominant parkinsonian phenotype, with mild and symmetric decreased binding in the member with the cerebellar phenotype, and normal in the asymptomatic member. The IBZM SPECT studies showed mild and asymmetrical reduction of the striatal dopamine D2 receptor density (parkinsonian members). SCA-3 can present with a levodopa responsive parkinsonism phenotype, and an abnormal DAT scan showing predominant impairment of presynaptic dopamine function.
Authors:
Esther Cubo; Mateo Diez López; Jon Infante Ceberio; Isabel Lanchas Alfonso; Begoña Miguel Martinez; José Berciano; Fernando Iglesias; José A Obeso
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Publication Detail:
Type:  Journal Article     Date:  2010-08-31
Journal Detail:
Title:  Journal of neurology     Volume:  258     ISSN:  1432-1459     ISO Abbreviation:  J. Neurol.     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-02-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0423161     Medline TA:  J Neurol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  308-10     Citation Subset:  IM    
Affiliation:
Department of Neurology, Hospital General Yagüe, Avda Cid 96, 09005, Burgos, Spain, esthercubo@gmail.com.
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