Document Detail


Striatal L-dopa metabolism studied in vivo in rats with nigrostriatal lesions.
MedLine Citation:
PMID:  2113388     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We have used cerebral dialysis to monitor striatal metabolism of exogenously administered L-dopa (L-dihydroxyphenylalanine) in rats with unilateral lesions of the substantia nigra. The concentration of extracellular dopamine (DA) increased in both striata following L-dopa administration but the increase was markedly attenuated in the lesioned striatum. The formation of dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA), the major DA metabolites, was also reduced in the lesioned striata following L-dopa administration; however, the reduction was not as great as was that of DA formation. A significant metabolism of exogenous L-dopa to 3-O-methyldopa occurred in both striata. L-dopa administration transiently increased extracellular levels of 5-hydroxyindoleacetic acid (5 HIAA) in both the lesioned and intact striata. These results suggest that the striatum with a reduction in DA nerve terminals is deficient both in the capacity to synthesize DA and in the storage mechanisms necessary to protect the newly synthesized DA from oxidative metabolism.
Authors:
T Brannan; A Bhardwaj; J Martinez-Tica; J Weinberger; M Yahr
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of neural transmission. Parkinson's disease and dementia section     Volume:  2     ISSN:  0936-3076     ISO Abbreviation:  J Neural Transm Park Dis Dement Sect     Publication Date:  1990  
Date Detail:
Created Date:  1990-08-02     Completed Date:  1990-08-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8914371     Medline TA:  J Neural Transm Park Dis Dement Sect     Country:  AUSTRIA    
Other Details:
Languages:  eng     Pagination:  15-22     Citation Subset:  IM    
Affiliation:
Department of Neurology, Mount Sinai School of Medicine, New York.
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MeSH Terms
Descriptor/Qualifier:
3,4-Dihydroxyphenylacetic Acid / metabolism
Animals
Corpus Striatum / metabolism*,  physiology
Dopamine / metabolism*
Homovanillic Acid / metabolism
Hydroxydopamines
Levodopa / metabolism*
Male
Oxidopamine
Rats
Rats, Inbred Strains
Substantia Nigra / physiology*
Chemical
Reg. No./Substance:
0/Hydroxydopamines; 0/Levodopa; 102-32-9/3,4-Dihydroxyphenylacetic Acid; 1199-18-4/Oxidopamine; 306-08-1/Homovanillic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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