Document Detail


Striatal FP-CIT uptake differs in the subtypes of early Parkinson's disease.
MedLine Citation:
PMID:  16715205     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In idiopathic Parkinson's disease (PD), a tremor-dominant type (TDT), an akinetic-rigid type (ART), and a mixed type (MT) are distinguished. We compared cerebral [I-123]FP-CIT SPECT in the PD subtypes (67 patients Hoehn and Yahr stage 1:26 with ART, 19 with MT, 22 with TDT). We measured the ratios putamen/occipital lobe binding and caudate nucleus/occipital lobe binding. Parkinsonian motor symptoms were quantified by UPDRS motor scale. In both putamen and caudate nucleus contralateral to the clinically affected body side TDT patients showed a significantly higher FP-CIT uptake than ART or MT patients (ANOVA; p<0.01). Contralateral putamen and caudate nucleus FP-CIT uptake correlated significantly with severity of rigidity (p<0.01) and hypokinesia (p<0.01) but not with severity of resting or postural tremor (p>0.05). The missing correlation between striatal FP-CIT uptake and tremor suggests, that further systems besides the nigrostriatal dopaminergic system may contribute to generation of parkinsonian tremor.
Authors:
J Spiegel; D Hellwig; S Samnick; W Jost; M-O Möllers; K Fassbender; C-M Kirsch; U Dillmann
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Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2006-05-24
Journal Detail:
Title:  Journal of neural transmission (Vienna, Austria : 1996)     Volume:  114     ISSN:  0300-9564     ISO Abbreviation:  J Neural Transm     Publication Date:  2007 Mar 
Date Detail:
Created Date:  2007-02-26     Completed Date:  2007-06-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9702341     Medline TA:  J Neural Transm     Country:  Austria    
Other Details:
Languages:  eng     Pagination:  331-5     Citation Subset:  IM    
Affiliation:
Department of Neurology, Saarland University, Homburg/Saar, Germany.
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MeSH Terms
Descriptor/Qualifier:
Adult
Age of Onset
Aged
Binding, Competitive / drug effects
Caudate Nucleus / metabolism,  physiopathology,  radionuclide imaging
Corpus Striatum / physiopathology,  radionuclide imaging*
Diagnosis, Differential
Disease Progression
Dopamine / metabolism*
Dopamine Plasma Membrane Transport Proteins / metabolism*
Female
Humans
Male
Middle Aged
Muscle Rigidity / metabolism,  physiopathology,  radionuclide imaging
Occipital Lobe / metabolism,  physiopathology,  radionuclide imaging
Parkinson Disease / diagnosis*,  physiopathology,  radionuclide imaging*
Predictive Value of Tests
Putamen / metabolism,  physiopathology,  radionuclide imaging
Substantia Nigra / metabolism,  physiopathology
Tomography, Emission-Computed, Single-Photon / methods
Tremor / metabolism,  physiopathology,  radionuclide imaging
Tropanes / diagnostic use*,  pharmacokinetics
Chemical
Reg. No./Substance:
0/Dopamine Plasma Membrane Transport Proteins; 0/Tropanes; 155797-99-2/2-carbomethoxy-8-(3-fluoropropyl)-3-(4-iodophenyl)tropane

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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