| Striatal dysfunction marks preexisting risk and medial prefrontal dysfunction is related to problem drinking in children of alcoholics. | |
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MedLine Citation:
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PMID: 20416863 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Parental alcoholism substantially raises risk for offspring alcoholism, an effect thought to be mediated by a dysregulation in impulse control. Adult alcoholics have alterations in the frontostriatal system involved in regulating impulsive responses. However, it remains controversial whether these alterations reflect preexisting traits predisposing to problem alcohol use or are secondary to alcohol involvement. METHODS: Sixty-one 16 to 22 year olds were tested using a go/no-go task during functional magnetic resonance imaging. Forty-one were family history positive (FH+), having at least one parent with a diagnosis of alcohol use disorder (AUD), and 20 were family history negative (FH-). Two FH+ subgroups were created to disentangle alcohol involvement from preexisting risk: the FH+ control group (n = 20) had low alcohol problems, differing from the FH- group only by family history. The FH+ problem group (n = 21) had high alcohol problems. RESULTS: The ventral caudate deactivated during successful inhibition in the FH- but not the FH+ groups, regardless of problem alcohol involvement. Regression analyses showed that ventral caudate deactivation was related to fewer externalizing problems as well as to family history. Orbital and left medial prefrontal regions were deactivated in both the FH- and FH+ control groups but not the FH+ problem group. Activation in these regions was associated with alcohol and other drug use. CONCLUSIONS: These findings suggest a preexisting abnormality in ventral striatal function in youth at risk for AUD, which may lead to inappropriate motivational responding, and suggest that with alcohol use, the prefrontal "control" mechanism loses efficiency, further dysregulating the frontostriatal motivational circuitry. |
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Authors:
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Mary M Heitzeg; Joel T Nigg; Wai-Ying Wendy Yau; Robert A Zucker; Jon-Kar Zubieta |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2010-04-22 |
Journal Detail:
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Title: Biological psychiatry Volume: 68 ISSN: 1873-2402 ISO Abbreviation: Biol. Psychiatry Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-07-20 Completed Date: 2010-11-22 Revised Date: 2012-05-08 |
Medline Journal Info:
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Nlm Unique ID: 0213264 Medline TA: Biol Psychiatry Country: United States |
Other Details:
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Languages: eng Pagination: 287-95 Citation Subset: IM |
Copyright Information:
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Copyright 2010 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Psychiatry, University of Michigan, Ann Arbor, Michigan, USA. mheitzeg@umich.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Alcohol Drinking / physiopathology, psychology Alcoholism* Analysis of Variance Basal Ganglia / physiology*, physiopathology Brain Mapping* Case-Control Studies Child of Impaired Parents* Choice Behavior* Discrimination (Psychology) / physiology Female Functional Laterality / physiology Humans Impulsive Behavior / physiopathology Inhibition (Psychology) Magnetic Resonance Imaging Male Prefrontal Cortex / physiology*, physiopathology Psychomotor Performance / physiology Reference Values Risk Factors Young Adult |
| Grant Support | |
ID/Acronym/Agency:
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K01 DA020088/DA/NIDA NIH HHS; K01 DA020088-01/DA/NIDA NIH HHS; R01 AA012217/AA/NIAAA NIH HHS; R01 AA012217-06/AA/NIAAA NIH HHS; R01 AA012217-10/AA/NIAAA NIH HHS; R01 AA12217/AA/NIAAA NIH HHS; R01 DA027261-03/DA/NIDA NIH HHS; R37 AA007065-16/AA/NIAAA NIH HHS; R37 AA007065-24/AA/NIAAA NIH HHS; R37 AA07065/AA/NIAAA NIH HHS |
| Comments/Corrections | |
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