| Stretching of homopolymeric RNA reveals single-stranded helices and base-stacking. | |
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MedLine Citation:
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PMID: 17501388 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We have found strong supporting evidence for the helical structures of single-stranded nucleic acids by stretching individual molecules of polyadenylic acid [poly(A)] and polycytidylic acid [poly(C)]. Analyzing the force versus extension data using a two-state elastic model in which random-coil domains alternate with rigid helical domains allows one to extract the thermodynamic and structural properties. In addition, it also yields moderate to low cooperativity of the helix-coil transition for poly(A) and poly(C), respectively. |
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Authors:
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Yeonee Seol; Gary M Skinner; Koen Visscher; Arnaud Buhot; Avraham Halperin |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2007-04-12 |
Journal Detail:
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Title: Physical review letters Volume: 98 ISSN: 0031-9007 ISO Abbreviation: Phys. Rev. Lett. Publication Date: 2007 Apr |
Date Detail:
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Created Date: 2007-05-15 Completed Date: 2007-06-19 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0401141 Medline TA: Phys Rev Lett Country: United States |
Other Details:
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Languages: eng Pagination: 158103 Citation Subset: IM |
Affiliation:
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Department of Physics, University of Arizona, Arizona 85721, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Elasticity Models, Chemical Nucleic Acid Conformation Poly A / chemistry* Poly C / chemistry* RNA / chemistry* Thermodynamics |
| Chemical | |
Reg. No./Substance:
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24937-83-5/Poly A; 30811-80-4/Poly C; 63231-63-0/RNA |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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