| Stretch-induced regional mechanoelectric dispersion and arrhythmia in the right ventricle of anesthetized lambs. | |
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MedLine Citation:
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PMID: 14766676 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Regional mechanical and electrophysiological changes accompany most ventricular arrhythmias and, it has been suggested, by mechanoelectric feedback. We hypothesized that an intervention producing regional mechanical dispersion was associated with regional, proarrhythmic electrical dispersion and studied the regional mechanoelectric feedback in the right ventricle (RV) of anesthetized lambs. Ten lambs were deeply anesthetized, and their hearts were exposed. Three tripodal devices, each incorporating three monophasic action potential electrodes and an integrated strain-gauge system, were placed on the RV apex outflow and inflow regions. Measurements were made before, during, and after 10-s pulmonary arterial occlusion. Pulmonary arterial occlusion increased RV pressure and overall regional segment length. Length excursion became out of phase with RV pressure beats immediately after occlusion, and the strain patterns were different in the three regions at the peak of occlusion. The occlusion resulted in different alterations in regional monophasic action potential morphology, including reduction in monophasic action potential amplitude and duration by different amounts and early afterdepolarizations that were unevenly distributed in the monophasic action potential recordings. This was associated with dispersion of repolarization and recovery time. The combination of electromechanical events precipitated a variety of arrhythmias. Acute RV distension is proarrhythmic, possibly through a causal relationship among mechanically induced afterdepolarizations, dispersion (heterogeneity) of mechanical strain, and dispersion of electrical recovery. The relationship among the different wall motions, the dispersion of repolarization, and arrhythmia underscored mechanoelectric feedback as an important part of arrhythmogenesis in pulmonary embolism and commotio cordis. |
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Authors:
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Ruo L Chen; Daniel J Penny; Gottfried Greve; Max J Lab |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: American journal of physiology. Heart and circulatory physiology Volume: 286 ISSN: 0363-6135 ISO Abbreviation: Am. J. Physiol. Heart Circ. Physiol. Publication Date: 2004 Mar |
Date Detail:
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Created Date: 2004-02-09 Completed Date: 2004-04-01 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 100901228 Medline TA: Am J Physiol Heart Circ Physiol Country: United States |
Other Details:
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Languages: eng Pagination: H1008-14 Citation Subset: IM |
Affiliation:
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Dept. of Physiology, Block 9, St. Thomas Campus, King's College, Univ. of London, Lambeth Palace Rd., London SE1 7BH, UK. ronnie.chen@kcl.ac.uk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Action Potentials
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physiology* Anesthesia Animals Arrhythmias, Cardiac / etiology, physiopathology* Feedback, Physiological / physiology Heart / physiopathology* Heart Ventricles / physiopathology Pulmonary Artery / physiopathology Pulmonary Embolism / physiopathology Sheep Stress, Mechanical |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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