| Stressor specificity of sex differences in hypothalamo-pituitary-adrenal axis activity: cortisol responses to exercise, endotoxin, wetting, and isolation/restraint stress in gonadectomized male and female sheep. | |
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MedLine Citation:
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PMID: 20668025 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Sex differences in the stress-induced activity of the hypothalamo-pituitary-adrenal axis in sheep appear to be dependent on the stressor encountered and occur irrespective of the presence of gonadal steroids. We tested the hypotheses that cortisol responses to exercise, endotoxin, wetting (experiment 1), and isolation/restraint (experiment 2) stress differ between gonadectomized male and female sheep. At weekly intervals (in experiment 1), we subjected gonadectomized rams and ewes (n = 6/group) to control conditions, to exercise stress, to iv injection of endotoxin, and to wetting stress. In a second experiment (experiment 2), we subjected gonadectomized rams and ewes (n = 5/group) to control conditions or to isolation/restraint stress. In both experiments, we measured plasma concentrations of cortisol before, during, and after stress at a frequency of at least 15 min with samples collected (from an indwelling jugular catheter) at a greater frequency around the time of the stressor. Cortisol responses to wetting (experiment 1) and isolation/restraint (experiment 2) stress were significantly higher in females compared with males but in response to exercise (experiment 1) and endotoxin (experiment 1) stress, there were no differences between the sexes. For some stressors, there are sex differences in sheep in the stress-induced activity of the hypothalamo-pituitary-adrenal axis that are independent of the presence of the sex steroids, but the existence of these sex differences and the direction of these sex differences differs, depending on the stressor imposed. |
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Authors:
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A I Turner; E T A Rivalland; I J Clarke; A J Tilbrook |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-07-28 |
Journal Detail:
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Title: Endocrinology Volume: 151 ISSN: 1945-7170 ISO Abbreviation: Endocrinology Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-08-25 Completed Date: 2010-10-04 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0375040 Medline TA: Endocrinology Country: United States |
Other Details:
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Languages: eng Pagination: 4324-31 Citation Subset: AIM; IM |
Affiliation:
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Department of Physiology, Monash University, Victoria 3800, Australia. anne.turner@deakin.edu.au |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Body Temperature Female Hydrocortisone / blood* Hypothalamo-Hypophyseal System / drug effects, physiology* Lipopolysaccharides / pharmacology Male Orchiectomy Ovariectomy Physical Conditioning, Animal / physiology Pituitary-Adrenal System / drug effects, physiology* Rectum / physiology Restraint, Physical Sex Factors Sheep Social Isolation Stress, Psychological / physiopathology* Time Factors Water / pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Lipopolysaccharides; 50-23-7/Hydrocortisone; 7732-18-5/Water |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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