Document Detail

Stressful life events and the onset of asthma.
MedLine Citation:
PMID:  21030455     Owner:  NLM     Status:  MEDLINE    
The status of stressful life events as a risk factor for asthma is unclear and may be dependent on pre-existing allergic rhinitis. This study examined whether exposure to stressful life events predicted the onset of asthma in adults. This is a prospective, population-based cohort study of 16,881 males and females, aged 20-54 yrs and free of diagnosed asthma at the beginning of the follow-up (January 1, 2004). Data about stressful life events were gathered with a postal survey. The onset of asthma was ascertained through national registers until December 31, 2005. During the follow-up period, 192 incident cases of asthma were identified. High total exposure to stressful life events, as indicated by a cumulative severity score, predicted the onset of asthma (hazard ratio 1.96, 95% CI 1.22-3.13). This association was robust to adjustment for demographics, smoking and having a cat/dog at home and it was observed both among those with and without allergic rhinitis at baseline. Of the 10 most stressful life events, the illness of a family member, marital problems, divorce or separation and conflicts with a supervisor were associated with the onset of asthma. Our study suggests that stressful life events may increase the onset of asthma.
R Lietzén; P Virtanen; M Kivimäki; L Sillanmäki; J Vahtera; M Koskenvuo
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2010-10-28
Journal Detail:
Title:  The European respiratory journal     Volume:  37     ISSN:  1399-3003     ISO Abbreviation:  Eur. Respir. J.     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2011-06-02     Completed Date:  2011-10-07     Revised Date:  2014-09-18    
Medline Journal Info:
Nlm Unique ID:  8803460     Medline TA:  Eur Respir J     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  1360-5     Citation Subset:  IM    
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MeSH Terms
Age of Onset
Asthma / epidemiology*,  etiology,  psychology*
Cohort Studies
Health Surveys / statistics & numerical data
Life Change Events
Longitudinal Studies
Middle Aged
Prospective Studies
Rhinitis, Allergic, Perennial / epidemiology
Smoking / epidemiology
Stress, Psychological / complications,  epidemiology*
Young Adult
Grant Support
G0902037//Medical Research Council; G19/35//Medical Research Council; G8802774//Medical Research Council; R01 AG013196/AG/NIA NIH HHS; R01 AG034454/AG/NIA NIH HHS; R01 AG034454-01/AG/NIA NIH HHS; R01 HL036310/HL/NHLBI NIH HHS; R01 HL036310-08/HL/NHLBI NIH HHS; R01AG034454/AG/NIA NIH HHS; R01HL036310/HL/NHLBI NIH HHS; RG/07/008/23674//British Heart Foundation

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