Document Detail

Stresses in peripheral arteries following stent placement: a finite element analysis.
MedLine Citation:
PMID:  18821189     Owner:  NLM     Status:  MEDLINE    
The success of stents to restore blood flow in atherosclerotic peripheral arteries is low relative to coronary arteries. It has been shown that joint flexion induces a mechanical environment that makes stent placement in these arteries highly incompatible, and damage and destruction of stents has been recorded. However, the effect of this environment on the stresses in the arteries is unknown. It is hypothesised that the stresses induced in arteries as a result of this mechanical environment could be sufficient to explain the relatively low success rates. To investigate this hypothesis, a finite element model of the stent-artery interaction was developed. Following stent expansion, bending was simulated by applying a displacement boundary condition to the artery. It is found that high stresses occur at the proximal/distal ends of the stent. As high stress and vascular injury are hypothesised to cause restenosis, the results presented here suggest that the mechanical environment of peripheral arteries could be the predominant cause of high restenosis rates.
Michael Early; Catriona Lally; Patrick J Prendergast; Daniel J Kelly
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Computer methods in biomechanics and biomedical engineering     Volume:  12     ISSN:  1025-5842     ISO Abbreviation:  Comput Methods Biomech Biomed Engin     Publication Date:  2009 Feb 
Date Detail:
Created Date:  2009-01-06     Completed Date:  2009-04-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9802899     Medline TA:  Comput Methods Biomech Biomed Engin     Country:  England    
Other Details:
Languages:  eng     Pagination:  25-33     Citation Subset:  IM    
Department of Mechanical and Manufacturing Engineering, Trinity College Dublin, Trinity Centre for Bioengineering, Dublin, Ireland.
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MeSH Terms
Arteries / physiology*
Blood Vessel Prosthesis*
Computer Simulation
Elastic Modulus / physiology
Finite Element Analysis
Graft Occlusion, Vascular / physiopathology*
Models, Cardiovascular*
Prosthesis Implantation*
Stress, Mechanical

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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