| Stress-vulnerability factors as long-term predictors of disease activity in early rheumatoid arthritis. | |
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MedLine Citation:
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PMID: 14507538 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Stress-vulnerability factors were studied for their ability to predict long-term disease activity in early rheumatoid arthritis. METHODS: In a prospective study involving 78 recently diagnosed rheumatoid arthritis (RA) patients, the role of personality characteristics (neuroticism, extraversion), physical and psychological stressors (chronic, disease-related stressors of functional disability, pain, disease impact on daily life, as well as major life events), coping and social support at the time of diagnosis was examined to predict changes in clinical indicators of disease activity 1, 3 and 5 years later. RESULTS: While stress-vulnerability factors failed to predict disease activity at the 1-year follow-up, disease activity at the 3- and 5-year follow-ups was predicted by coping and social support at the time of diagnosis, after adjusting for disease activity at first assessment, other biomedical and psychosocial factors and use of medication. Low levels of social support predicted increased disease activity at the 3-year follow-up, and high avoidance coping predicted increased disease activity at the 3- and 5-year follow-ups. CONCLUSION: Findings indicate the potential prognostic value of avoidance coping and social support for the long-term course of disease activity in early RA and suggest that the effects of these vulnerability factors predominantly operate in the long term. |
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Authors:
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Andrea W M Evers; Floris W Kraaimaat; Rinie Geenen; Johannes W G Jacobs; Johannes W J Bijlsma |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of psychosomatic research Volume: 55 ISSN: 0022-3999 ISO Abbreviation: J Psychosom Res Publication Date: 2003 Oct |
Date Detail:
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Created Date: 2003-09-25 Completed Date: 2004-02-19 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0376333 Medline TA: J Psychosom Res Country: England |
Other Details:
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Languages: eng Pagination: 293-302 Citation Subset: IM |
Affiliation:
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Department of Medical Psychology 118, University Medical Center St Radboud, PO Box 9101, 6500 HB, Nijmegen, The Netherlands. a.evers@cukz.umcn.nl |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Activities of Daily Living Adaptation, Psychological* Adult Aged Aged, 80 and over Arthritis, Rheumatoid / psychology* Disease Progression Female Humans Male Middle Aged Prognosis Prospective Studies Risk Factors Social Support Stress, Psychological* |
| Comments/Corrections | |
Comment In:
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J Psychosom Res. 2003 Oct;55(4):303-4
[PMID:
14507539
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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