| Stress up-regulates neuronal expression of the herpes simplex virus type 2 large subunit of ribonucleotide reductase (R1; ICP10) by activating activator protein 1. | |
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MedLine Citation:
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PMID: 16162476 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Herpes simplex virus type 2 (HSV-2) genes expressed in neuronal cells in response to stress stimuli that trigger latency reactivation are largely unknown. Using a chloramphenicol acetyltransferase (CAT) reporter assay we found that stress caused a significant (P < .001) increase in ICP10 expression in neuronal cells. Up-regulation correlated with activator protein (AP)-1 activation, notably c-Jun and c-Fos that bind cognate elements in the ICP10 promoter. It was blocked by mutation of the AP-1 motifs in the ICP10 promoter. ICP10 expression protected neuronal cells from stress-induced apoptosis. The data suggest that ICP10 may contribute to HSV-2 reactivation by increasing neuronal survival. |
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Authors:
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Michael D Gober; Samantha Q Wales; J Colin Hunter; Bhuvnesh K Sharma; Laure Aurelian |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Journal of neurovirology Volume: 11 ISSN: 1355-0284 ISO Abbreviation: J. Neurovirol. Publication Date: 2005 Aug |
Date Detail:
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Created Date: 2005-09-15 Completed Date: 2005-10-25 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 9508123 Medline TA: J Neurovirol Country: United States |
Other Details:
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Languages: eng Pagination: 329-36 Citation Subset: IM |
Affiliation:
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Department of Pharmacology and Experimental Therapeutics, University of Maryland School of Medicine, Baltimore, Maryland 21201-1559, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acid Sequence Animals Cell Survival Gene Expression Regulation, Viral Genes, Reporter Heat-Shock Response Herpes Genitalis / virology* Herpesvirus 2, Human / genetics*, growth & development Molecular Sequence Data Neurons / cytology, physiology, virology* PC12 Cells Promoter Regions, Genetic / physiology Protein-Serine-Threonine Kinases / genetics* Rats Ribonucleotide Reductases / genetics* Transcription Factor AP-1 / metabolism* Up-Regulation |
| Grant Support | |
ID/Acronym/Agency:
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NS45169/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Transcription Factor AP-1; EC 1.17.4-/ICP10 protein, herpes simplex virus type 2; EC 1.17.4.-/Ribonucleotide Reductases; EC 2.7.11.1/Protein-Serine-Threonine Kinases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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