| Stress susceptibility as a determinant of the response to adrenergic stimuli in mesenteric resistance arteries of the rat. | |
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MedLine Citation:
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PMID: 12409976 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Characterized by the behavioral response to apomorphine, two outbred lines of Wistar rats can be recognized with constitutionally determined high (apomorphine susceptible, APO-SUS) or low (apomorphine unsusceptible, APO-UNSUS) adrenal responses to similar environmental stress. Within the accumbens nucleus, the APO-SUS and APO-UNSUS rats differ in alpha -adrenergic receptor responsiveness. This study explored whether these differences in adrenergic receptor sensitivity also exist in mesenteric resistance arteries. A Mulvany myograph was used to study the vasomotor responses of isolated mesenteric resistance arteries to adrenergic receptor stimulation. Phenylephrine (alpha1-agonist)-induced vasoconstriction did not differ between the two lines (pEC : 5.8 +/- 0.05 microM versus 5.8 +/- 0.04 microM and Emax: 36 +/- 2 kPa versus 33 +/- 1 kPa for APO-SUS, n = 9, and APO-UNSUS, n = 11, respectively, p > 0.1). After precontraction with phenylephrine, salbutamol (beta -agonist)-induced relaxation was less in APO-SUS rats (pEC50 4.9 +/- 0.06 versus 5.3 +/- 0.06M for APO-SUS, n = 9, and APO-UNSUS, n = 7, respectively, p < 0.001). Likewise, clonidine (alpha2-agonist)-induced relaxation was reduced in APO-SUS rats (pEC50: 6.7 +/- 0.07 versus 7.0 +/- 0.04, for APO-SUS, n = 9, and APO-UNSUS, n = 8, respectively; p < 0.01). In conclusion, constitutionally determined high susceptibility to stress is accompanied by an impaired vasorelaxation to adrenergic stimuli whereas vasoconstriction is unaffected. An unopposed vasoconstrictor action of norepinephrine may place the APO-SUS rats at increased risk for the development of hypertension, insulin resistance, and atherosclerosis. |
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Authors:
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Bart W Smits; Helene L M Siero; Bart A Ellenbroek; Niels P Riksen; Alexander R Cools; Joop M P M Borggreven; Gerard A Rongen; Frans G M Russel; Paul Smits |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of cardiovascular pharmacology Volume: 40 ISSN: 0160-2446 ISO Abbreviation: J. Cardiovasc. Pharmacol. Publication Date: 2002 Nov |
Date Detail:
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Created Date: 2002-10-31 Completed Date: 2003-03-04 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7902492 Medline TA: J Cardiovasc Pharmacol Country: United States |
Other Details:
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Languages: eng Pagination: 678-83 Citation Subset: IM |
Affiliation:
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Department of Pharmacology-Toxicology, University Medical Center Nijmegen, Nijmegen, the Netherlands. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Apomorphine / administration & dosage, pharmacology* Dopamine Agonists / administration & dosage, pharmacology* Dose-Response Relationship, Drug Drug Interactions Male Mesenteric Arteries / drug effects Phenylephrine / pharmacology Rats Receptors, Adrenergic / drug effects* Vasoconstriction / drug effects* Vasoconstrictor Agents / pharmacology Vasodilation / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Dopamine Agonists; 0/Receptors, Adrenergic; 0/Vasoconstrictor Agents; 58-00-4/Apomorphine; 59-42-7/Phenylephrine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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