Document Detail


Stress signaling in cancer.
MedLine Citation:
PMID:  17645775     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The human body is continuously exposed to a wide variety of physical, chemical, and biological stress stimuli from both the external and internal environments. In order to adapt to or resist stress, cells are equipped with multiple signaling systems, which elicit a wide range of stress responses. Stress signaling also operates to eliminate cells with severe stress-induced damage through the induction of apoptosis. Once stress signaling is compromised in certain adverse conditions, however, cells exhibit aberrant responses to stress, which can eventually cause various diseases including cancer. In the present review, the authors focus on the current understanding of the critical linkage between stress signaling and cancer.
Authors:
Shiori Murakami; Takuya Noguchi; Kohsuke Takeda; Hidenori Ichijo
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2007-07-23
Journal Detail:
Title:  Cancer science     Volume:  98     ISSN:  1347-9032     ISO Abbreviation:  Cancer Sci.     Publication Date:  2007 Oct 
Date Detail:
Created Date:  2007-08-31     Completed Date:  2007-11-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101168776     Medline TA:  Cancer Sci     Country:  England    
Other Details:
Languages:  eng     Pagination:  1521-7     Citation Subset:  IM    
Affiliation:
Laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, The University of Tokyo, CREST, Japan Science and Technology Corporation, Bunkyo-ku, Tokyo 113-0033, Japan.
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MeSH Terms
Descriptor/Qualifier:
Animals
Humans
Neoplasms / metabolism*,  pathology
Oxidative Stress / physiology*
Signal Transduction / physiology*

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