| Stress responses after treatment of hypercholesterolaemia with simvastatin. | |
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MedLine Citation:
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PMID: 12959299 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In order to determine whether treatment of hyperlipidaemia with simvastatin impairs exercise stress responses and so may contribute to an excess of suicides and violent deaths, the effects of simvastatin 20 mg daily and placebo on exercise physiology were compared in 19 patients. After 6 weeks of treatment there was no evidence of reduced exercise capacity, or of reduced cortisol or catecholamine responses. It is concluded that treatment of hyperlipidaemia with an inhibitor of HMG-CoA reductase does not significantly modify stress responses, and so the explanation for a possible increase in non-cardiac mortality must be sought elsewhere. |
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Authors:
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A M Nugent; D Neely; I Young; I McDowell; M O'Kane; N Bell; C F Stanford; D P Nicholls |
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Publication Detail:
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Type: Clinical Trial; Controlled Clinical Trial; Journal Article |
Journal Detail:
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Title: British journal of clinical pharmacology Volume: 36 ISSN: 0306-5251 ISO Abbreviation: Br J Clin Pharmacol Publication Date: 1993 Nov |
Date Detail:
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Created Date: 2003-09-08 Completed Date: 2003-09-17 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 7503323 Medline TA: Br J Clin Pharmacol Country: England |
Other Details:
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Languages: eng Pagination: 474-7 Citation Subset: IM |
Affiliation:
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Royal Victoria Hospital, Belfast BT12 6BA, Northern Ireland. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adrenocorticotropic Hormone
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metabolism Adult Anticholesteremic Agents / therapeutic use* Blood Pressure / drug effects Exercise / physiology* Exercise Test Female Heart Rate / drug effects Humans Hypercholesterolemia / drug therapy* Male Middle Aged Simvastatin / therapeutic use* Stress, Physiological / etiology* |
| Chemical | |
Reg. No./Substance:
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0/Anticholesteremic Agents; 79902-63-9/Simvastatin; 9002-60-2/Adrenocorticotropic Hormone |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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