Document Detail

Stress-related preeclampsia: an evolutionary maladaptation in exaggerated stress during pregnancy?
MedLine Citation:
PMID:  12581605     Owner:  NLM     Status:  MEDLINE    
The authors hypothesize that preeclampsia is a stress-related disease and an evolutionary maladaptation of exaggerated stress during human pregnancy. Epidemiologic studies show that relative risk for preeclampsia is increased in many stressful situations. Many risk factors for preeclampsia are stress-related. Low-stress situations, on the contrary, are protective. Stress in pregnancy corroborates all physiopathologic theories for preeclampsia; it does not contradict them. Animals exposed to intense stress show many characteristics of preeclampsia, and some animal models for human preeclampsia have been proposed. The stress-alarm reaction is protective for survival in animals. But the evolutionary maladaptation of this intense stress could lead to preeclampsia in humans.
N H Takiuti; S Kahhale; M Zugaib
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Medical hypotheses     Volume:  60     ISSN:  0306-9877     ISO Abbreviation:  Med. Hypotheses     Publication Date:  2003 Mar 
Date Detail:
Created Date:  2003-02-12     Completed Date:  2003-10-01     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7505668     Medline TA:  Med Hypotheses     Country:  Scotland    
Other Details:
Languages:  eng     Pagination:  328-31     Citation Subset:  IM    
São Paulo University Medical School, Brazil.
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MeSH Terms
Disease Models, Animal
Models, Theoretical
Pre-Eclampsia / etiology*
Rats, Wistar
Risk Factors
Stress, Physiological*

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