| Stress-related mucosal damage: critical evaluation of potential new therapeutic agents. | |
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MedLine Citation:
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PMID: 3328166 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cell injury produced by hydrochloric acid is the final common denominator for stress-related mucosal damage. Actions of therapeutic agents designed to prevent such damage are directed toward either inhibiting acid secretion or stimulating protective mechanisms. Newer agents that fall into the former category include omeprazole, an inhibitor of the H+-K+-ATPase pump, prostaglandins, and somatostatin. In addition to inhibiting acid, prostaglandins stimulate mucus and bicarbonate secretion and therefore provide a two-pronged protective action. Tranexamic acid is an antifibrinolytic agent that is postulated to promote clotting at bleeding sites in upper gastrointestinal lesions. Analyses of composite data suggest that (1) prostaglandin E preparations appear to be as effective as currently recognized forms of therapy, such as antacid and H2-receptor antagonist administration; (2) little enthusiasm can currently be generated for use of somatostatin or tranexamic acid; and (3) omeprazole is a theoretically attractive agent that remains to be tested in the prophylactic treatment of gastrointestinal ulceration due to severe stress. |
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Authors:
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R G Knodell; L E Rosenthal |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Pharmacotherapy Volume: 7 ISSN: 0277-0008 ISO Abbreviation: Pharmacotherapy Publication Date: 1987 |
Date Detail:
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Created Date: 1988-04-27 Completed Date: 1988-04-27 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 8111305 Medline TA: Pharmacotherapy Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 104S-109S Citation Subset: IM |
Affiliation:
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Division of Gastroenterology, University of Maryland Hospital, Baltimore 21201. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anti-Ulcer Agents
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therapeutic use* Humans Stomach Ulcer / drug therapy*, etiology Stress, Physiological / complications* |
| Chemical | |
Reg. No./Substance:
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0/Anti-Ulcer Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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