Document Detail

Stress-related mucosal damage: critical evaluation of potential new therapeutic agents.
MedLine Citation:
PMID:  3328166     Owner:  NLM     Status:  MEDLINE    
Cell injury produced by hydrochloric acid is the final common denominator for stress-related mucosal damage. Actions of therapeutic agents designed to prevent such damage are directed toward either inhibiting acid secretion or stimulating protective mechanisms. Newer agents that fall into the former category include omeprazole, an inhibitor of the H+-K+-ATPase pump, prostaglandins, and somatostatin. In addition to inhibiting acid, prostaglandins stimulate mucus and bicarbonate secretion and therefore provide a two-pronged protective action. Tranexamic acid is an antifibrinolytic agent that is postulated to promote clotting at bleeding sites in upper gastrointestinal lesions. Analyses of composite data suggest that (1) prostaglandin E preparations appear to be as effective as currently recognized forms of therapy, such as antacid and H2-receptor antagonist administration; (2) little enthusiasm can currently be generated for use of somatostatin or tranexamic acid; and (3) omeprazole is a theoretically attractive agent that remains to be tested in the prophylactic treatment of gastrointestinal ulceration due to severe stress.
R G Knodell; L E Rosenthal
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Pharmacotherapy     Volume:  7     ISSN:  0277-0008     ISO Abbreviation:  Pharmacotherapy     Publication Date:  1987  
Date Detail:
Created Date:  1988-04-27     Completed Date:  1988-04-27     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8111305     Medline TA:  Pharmacotherapy     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  104S-109S     Citation Subset:  IM    
Division of Gastroenterology, University of Maryland Hospital, Baltimore 21201.
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MeSH Terms
Anti-Ulcer Agents / therapeutic use*
Stomach Ulcer / drug therapy*,  etiology
Stress, Physiological / complications*
Reg. No./Substance:
0/Anti-Ulcer Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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