Document Detail

Stress reduces conception probabilities across the fertile window: evidence in support of relaxation.
MedLine Citation:
PMID:  20688324     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To assess salivary stress biomarkers (cortisol and α-amylase) and female fecundity.
DESIGN: Prospective cohort design.
SETTING: United Kingdom.
PATIENT(S): 274 women aged 18 to 40 years who were attempting pregnancy.
INTERVENTION(S): Observation for six cycles or until pregnancy: women collected basal saliva samples on day 6 of each cycle, and used fertility monitors to identify ovulation and pregnancy test kits for pregnancy detection.
MAIN OUTCOME MEASURE(S): Salivary cortisol (μg/dL) and α-amylase (U/mL) concentration measurements; fecundity measured by time-to-pregnancy and the probability of pregnancy during the fertile window as estimated from discrete-time survival and Bayesian modeling techniques, respectively.
RESULT(S): Alpha-amylase but not cortisol concentrations were negatively associated with fecundity in the first cycle (fecundity odds ratio=0.85; 95% confidence interval 0.67, 1.09) after adjusting for the couples' ages, intercourse frequency, and alcohol consumption. Statistically significant reductions in the probability of conception across the fertile window during the first cycle attempting pregnancy were observed for women whose salivary concentrations of α-amylase were in the upper quartiles in comparison with women in the lower quartiles (highest posterior density: -0.284; 95% interval -0.540, -0.029).
CONCLUSION(S): Stress significantly reduced the probability of conception each day during the fertile window, possibly exerting its effect through the sympathetic medullar pathway.
Germaine M Buck Louis; Kirsten J Lum; Rajeshwari Sundaram; Zhen Chen; Sungduk Kim; Courtney D Lynch; Enrique F Schisterman; Cecilia Pyper
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Publication Detail:
Type:  Comment; Journal Article; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't     Date:  2010-08-05
Journal Detail:
Title:  Fertility and sterility     Volume:  95     ISSN:  1556-5653     ISO Abbreviation:  Fertil. Steril.     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2011-05-23     Completed Date:  2011-07-28     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2184-9     Citation Subset:  IM    
Copyright Information:
Published by Elsevier Inc.
Division of Epidemiology, Statistics, and Prevention Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Rockville, Maryland 20852, USA.
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MeSH Terms
Bayes Theorem
Biological Markers / metabolism
Chi-Square Distribution
Great Britain
Hydrocortisone / metabolism*
Infertility, Female / etiology*,  metabolism,  physiopathology,  prevention & control
Odds Ratio
Ovarian Function Tests
Pregnancy Rate
Pregnancy Tests
Proportional Hazards Models
Prospective Studies
Risk Assessment
Risk Factors
Saliva / enzymology*
Stress, Psychological / complications*,  metabolism,  physiopathology,  prevention & control
Young Adult
alpha-Amylases / metabolism*
Grant Support
Z01 HD008774-03/HD/NICHD NIH HHS
Reg. No./Substance:
0/Biological Markers; 50-23-7/Hydrocortisone; EC
Comment On:
Fertil Steril. 2011 Jun;95(7):2190-1   [PMID:  21601665 ]
Comment In:
Fertil Steril. 2011 Jun 30;95(8):2462-3   [PMID:  21704209 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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