| Stress reduces conception probabilities across the fertile window: evidence in support of relaxation. | |
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MedLine Citation:
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PMID: 20688324 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To assess salivary stress biomarkers (cortisol and α-amylase) and female fecundity. DESIGN: Prospective cohort design. SETTING: United Kingdom. PATIENT(S): 274 women aged 18 to 40 years who were attempting pregnancy. INTERVENTION(S): Observation for six cycles or until pregnancy: women collected basal saliva samples on day 6 of each cycle, and used fertility monitors to identify ovulation and pregnancy test kits for pregnancy detection. MAIN OUTCOME MEASURE(S): Salivary cortisol (μg/dL) and α-amylase (U/mL) concentration measurements; fecundity measured by time-to-pregnancy and the probability of pregnancy during the fertile window as estimated from discrete-time survival and Bayesian modeling techniques, respectively. RESULT(S): Alpha-amylase but not cortisol concentrations were negatively associated with fecundity in the first cycle (fecundity odds ratio=0.85; 95% confidence interval 0.67, 1.09) after adjusting for the couples' ages, intercourse frequency, and alcohol consumption. Statistically significant reductions in the probability of conception across the fertile window during the first cycle attempting pregnancy were observed for women whose salivary concentrations of α-amylase were in the upper quartiles in comparison with women in the lower quartiles (highest posterior density: -0.284; 95% interval -0.540, -0.029). CONCLUSION(S): Stress significantly reduced the probability of conception each day during the fertile window, possibly exerting its effect through the sympathetic medullar pathway. |
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Authors:
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Germaine M Buck Louis; Kirsten J Lum; Rajeshwari Sundaram; Zhen Chen; Sungduk Kim; Courtney D Lynch; Enrique F Schisterman; Cecilia Pyper |
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Publication Detail:
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Type: Comment; Journal Article; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't Date: 2010-08-05 |
Journal Detail:
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Title: Fertility and sterility Volume: 95 ISSN: 1556-5653 ISO Abbreviation: Fertil. Steril. Publication Date: 2011 Jun |
Date Detail:
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Created Date: 2011-05-23 Completed Date: 2011-07-28 Revised Date: 2011-08-12 |
Medline Journal Info:
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Nlm Unique ID: 0372772 Medline TA: Fertil Steril Country: United States |
Other Details:
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Languages: eng Pagination: 2184-9 Citation Subset: IM |
Copyright Information:
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Published by Elsevier Inc. |
Affiliation:
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Division of Epidemiology, Statistics, and Prevention Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Rockville, Maryland 20852, USA. louisg@mail.nih.gov |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Bayes Theorem Biological Markers / metabolism Chi-Square Distribution Female Fertility* Great Britain Humans Hydrocortisone / metabolism* Infertility, Female / etiology*, metabolism, physiopathology, prevention & control Odds Ratio Ovarian Function Tests Ovulation Pregnancy Pregnancy Rate Pregnancy Tests Proportional Hazards Models Prospective Studies Risk Assessment Risk Factors Saliva / enzymology* Stress, Psychological / complications*, metabolism, physiopathology, prevention & control Young Adult alpha-Amylases / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 50-23-7/Hydrocortisone; EC 3.2.1.1/alpha-Amylases |
| Comments/Corrections | |
Comment On:
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Fertil Steril. 2011 Jun;95(7):2190-1
[PMID:
21601665
]
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Comment In:
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Fertil Steril. 2011 Jun 30;95(8):2462-3
[PMID:
21704209
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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