Document Detail

Stress presents a problem for dendritic cells: corticosterone and the fate of MHC class I antigen processing and presentation.
MedLine Citation:
PMID:  16504465     Owner:  NLM     Status:  MEDLINE    
Corticosterone (cortisol in humans), a glucocorticoid hormone released into circulation in response to psychological stress via the hypothalamic-pituitary-adrenal axis, can undermine primary and memory CD8(+) cytotoxic T lymphocyte (CTL) responses. These CTL responses are vital for fighting intracellular pathogens, such as viruses, and some tumors. Dendritic cells (DCs) play a pivotal role in the generation of both primary and memory CTL responses. DCs are specialized for antigen acquisition (by direct infection or uptake from neighboring cells), transport, processing, and MHC class I-restricted presentation of antigen to CTL. These are critical events that are an absolute requirement for the generation of CTL responses regardless of any other immune responses that may be occurring. This minireview provides an overview of the components of MHC class I antigen processing and presentation pathway and describes our recent published work on the effects of corticosterone on this process in virally infected DCs. Corticosterone impairs the efficiency with which antigen is presented on DCs. The mechanism of this impairment is shown to be via a reduction in the generation of antigenic peptide from virally expressed protein. This impairment of antigen processing and presentation by corticosterone was also observed in non-immune cells, suggesting that stress may affect essential cellular protein management functions in all cells, and having possible implications for neurological or other diseases that may result from aberrant protein processing.
M E Truckenmiller; Robert H Bonneau; Christopher C Norbury
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Publication Detail:
Type:  Journal Article; Review     Date:  2006-02-28
Journal Detail:
Title:  Brain, behavior, and immunity     Volume:  20     ISSN:  0889-1591     ISO Abbreviation:  Brain Behav. Immun.     Publication Date:  2006 May 
Date Detail:
Created Date:  2006-04-17     Completed Date:  2006-07-26     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8800478     Medline TA:  Brain Behav Immun     Country:  United States    
Other Details:
Languages:  eng     Pagination:  210-8     Citation Subset:  IM    
Department of Microbiology and Immunology, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA.
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MeSH Terms
Antigen Presentation / physiology*
Cell Line
Corticosterone / physiology*
Dendritic Cells / immunology*
Histocompatibility Antigens Class I / immunology*
Mice, Inbred C57BL
Stress, Physiological / immunology*
T-Lymphocytes / immunology
Virus Diseases / immunology
Reg. No./Substance:
0/Histocompatibility Antigens Class I; 50-22-6/Corticosterone

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