Document Detail


Stress and oesophageal motility in normal subjects and patients with irritable bowel syndrome.
MedLine Citation:
PMID:  2599439     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Patterns of oesophageal motility were recorded in 17 healthy volunteers and 12 patients with the irritable bowel syndrome. Recordings were taken at rest and under stress by hyperventilation, a dichotic hearing challenge and a cold pressor test. In healthy volunteers the dichotic hearing challenge was associated with a significant increase in the mean amplitude of oesophageal peristalsis from 69.9 mmHg to 82.4 mmHg (p less than 0.01) and in the percentage of simultaneous waves from 9.7% to 24.5% (p less than 0.01). The cold pressor test increased the peristaltic amplitude from 69.9 mmHg to 87.1 mmHg (p less than 0.001) and the percentage of simultaneous waves from 9.7% to 34.4% (p less than 0.01). Both manoeuvres were associated with increases in pulse and blood pressure. In patients with irritable bowel syndrome, the resting mean oesophageal peristaltic amplitude was higher than that seen in normal volunteers (95.9 mmHg v 69.9 mmHg p less than 0.05). Changes in oesophageal motility during stress were similar in these patients to those seen in normal subjects although the changes were not significant. This study refutes the hypothesis that symptoms of irritable bowel syndrome and their association with stress are attributable to increased sensitivity of oesophageal motility to disruption by stressful stimuli.
Authors:
R C Ayres; D A Robertson; K Naylor; C L Smith
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Gut     Volume:  30     ISSN:  0017-5749     ISO Abbreviation:  Gut     Publication Date:  1989 Nov 
Date Detail:
Created Date:  1990-02-02     Completed Date:  1990-02-02     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  2985108R     Medline TA:  Gut     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1540-3     Citation Subset:  AIM; IM    
Affiliation:
Department of Medicine 2, Southampton General Hospital, Hampshire.
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MeSH Terms
Descriptor/Qualifier:
Adult
Colonic Diseases, Functional / complications,  physiopathology*
Esophageal Motility Disorders / etiology
Esophagus / physiopathology*
Female
Humans
Male
Middle Aged
Peristalsis
Reference Values
Stress, Physiological / physiopathology*
Comments/Corrections

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