| Stress modulates cholesterol-induced changes in plasma and liver fatty acid composition in rats fed n-6 fatty acid-rich oils. | |
| | |
MedLine Citation:
|
PMID: 2399256 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The effects of dietary cholesterol (CH) and isolation stress on fatty acid compositions of plasma and liver cholesteryl ester and phospholipids were compared in growing rats fed an 18:2n-6 or an 18:3n-6 enriched semisynthetic diet for 2 weeks. Stress, CH-feeding, and dietary fats had no significant effects on plasma CH level, but CH-feeding alone elevated the liver CH concentrations. CH-feeding also modulated the liver polyunsaturated fatty acid compositions, i.e., increasing 18:2n-6 levels, and reducing 20:4n-6 levels, indicating an inhibition of the enzymes, delta-6 and delta-5-desaturases. The extent of these changes was less in rats fed 18:3n-6 than in those fed 18:2n-6. Stress, which alone had no significant effects on plasma and liver fatty acid compositions, attenuated the CH-induced changes of fatty acid levels. |
| | |
Authors:
|
Y S Huang; D E Mills; R P Ward; V A Simmons; D F Horrobin |
Related Documents
:
|
5465366 - Absence of cystathionase in human fetal liver: is cystine essential? 10713486 - Metabolism of 4-hydroxynonenal, a cytotoxic product of lipid peroxidation, in rat preci... 18274956 - Metabolism and related human risk factors for hepatic damage by usnic acid containing n... 706936 - Studies on the fatty acid synthesis in maternal and fetal rats. 21733326 - Resveratrol attenuates steatosis in obese zucker rats by decreasing fatty acid availabi... 6196026 - Mg2+-, ca2+-dependent unwinding of dna by poly-l-glutamic acid. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.) Volume: 195 ISSN: 0037-9727 ISO Abbreviation: Proc. Soc. Exp. Biol. Med. Publication Date: 1990 Oct |
Date Detail:
|
Created Date: 1990-10-18 Completed Date: 1990-10-18 Revised Date: 2008-11-21 |
Medline Journal Info:
|
Nlm Unique ID: 7505892 Medline TA: Proc Soc Exp Biol Med Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 136-41 Citation Subset: IM |
Affiliation:
|
Efamol Research Institute, Kentville, Nova Scotia, Canada. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Antilipemic Agents / administration & dosage Blood Pressure Cholesterol, Dietary / administration & dosage, pharmacology* Diet, Atherogenic Dietary Fats, Unsaturated / administration & dosage, pharmacology* Fatty Acids, Essential / administration & dosage, analysis, blood Fatty Acids, Unsaturated / administration & dosage, analysis*, blood Linoleic Acids Liver / analysis Male Plant Oils Rats Rats, Inbred WKY Safflower Oil / administration & dosage Stress, Physiological / metabolism* Weight Gain gamma-Linolenic Acid |
| Chemical | |
Reg. No./Substance:
|
0/Antilipemic Agents; 0/Cholesterol, Dietary; 0/Dietary Fats, Unsaturated; 0/Fatty Acids, Essential; 0/Fatty Acids, Unsaturated; 0/Linoleic Acids; 0/Plant Oils; 506-26-3/gamma-Linolenic Acid; 65546-85-2/Efamol; 8001-23-8/Safflower Oil |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The influence of 24,25(OH)2D3 on the calcemic effect of 1,25(OH)2D in rats with chronic renal failur...
Next Document: Digitalis attenuates arterial hypertrophy in experimental hypertension.