Document Detail

Stress mediators in the amniotic compartment in relation to the degree of fetal distress.
MedLine Citation:
PMID:  7818778     Owner:  NLM     Status:  MEDLINE    
In an attempt to locate biochemical markers specific for fetal distress we measured the amniotic concentrations of beta-endorphin, ACTH, cortisol, dopamine, norepinephrine and epinephrine with its major metabolite metanephrine (MN) in pregnancies with documented fetal well-being and pregnancies complicated by hypertension and fetal distress. While higher levels of cortisol and MN were found only in a selected subgroup of highly compromised subjects (p < 0.001 and p < 0.005, respectively), beta-endorphin increased significantly under conditions of moderate or severe intrauterine sufferance (p < 0.001 in both cases). Due to higher levels of the opioid even during the initial stage of fetal discomfort we evaluated its characteristics as a possible clinical marker. Specificity was 88.5%, whereas the sensitivity of 65.6% in the moderately compromised subgroup increased to 88.9% in severely suffering fetuses. Although more accurate and mainly real-time information on the fetal health status is obtained by means of biophysical methods, the determination of amniotic fluid beta-endorphin might be of clinical usefulness in prenatal diagnosis.
A Mauri; A Volpe
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Fetal diagnosis and therapy     Volume:  9     ISSN:  1015-3837     ISO Abbreviation:  Fetal. Diagn. Ther.     Publication Date:    1994 Sep-Oct
Date Detail:
Created Date:  1995-02-16     Completed Date:  1995-02-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9107463     Medline TA:  Fetal Diagn Ther     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  300-5     Citation Subset:  IM    
Department of Obstetrics and Gynecology, University of Cagliari, Italy.
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MeSH Terms
Adrenocorticotropic Hormone / analysis
Amniotic Fluid / chemistry*
Biological Markers*
Dopamine / analysis
Epinephrine / analysis
Fetal Distress*
Hydrocortisone / analysis
Metanephrine / analysis
Norepinephrine / analysis
beta-Endorphin / analysis
Reg. No./Substance:
0/Biological Markers; 50-23-7/Hydrocortisone; 5001-33-2/Metanephrine; 51-41-2/Norepinephrine; 51-43-4/Epinephrine; 60617-12-1/beta-Endorphin; 9002-60-2/Adrenocorticotropic Hormone

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