Document Detail

Stress management and psychoneuroimmunology in HIV infection.
MedLine Citation:
PMID:  12627048     Owner:  NLM     Status:  MEDLINE    
Does stress management affect psychological and immune functioning in persons with human immunodeficiency virus infections? Stress-management techniques, such as relaxation training and imagery, cognitive restructuring, coping-skills training, and interpersonal-skills training, may reduce anxiety, depression, and social isolation in HIV-infected persons by lowering physical tension and increasing a sense of control and self-efficacy. A psychoneuroimmunologic model is proposed wherein these psychological changes are hypothesized to be accompanied by an improved ability to regulate neuroendocrine functioning, which in turn may be associated with a partial normalization of immune system functions such as lymphocyte proliferation and cytotoxicity, providing more efficient surveillance of latent viruses that may contribute directly to increased HIV replication and generate opportunistic infections or cancer if left unchecked. Such a normalization of stress-associated immune system decrements are hypothesized to forestall or minimize increases in viral load and expression of clinical symptoms. This model is useful for testing the factors contributing to the health effects of stress-management interventions in HIV-infected persons. In this context, one general research strategy for testing the effects of stress-management interventions is to target them toward the more prevalent psychosocial challenges that HIV-infected people face at various points in the disease process; enroll an HIV-infected population (eg, HIV-positive homosexual and bisexual men) into a randomized trial; and monitor changes in cognitive, affective, behavioral, and social factors in parallel with hormonal, immunologic, viral, and clinical changes over the course of time. This article will review the major psychoneuroimmunologic findings that have emerged using this paradigm and suggest future research directions and clinical applications.
Michael H Antoni
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  CNS spectrums     Volume:  8     ISSN:  1092-8529     ISO Abbreviation:  CNS Spectr     Publication Date:  2003 Jan 
Date Detail:
Created Date:  2003-03-10     Completed Date:  2003-04-17     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9702877     Medline TA:  CNS Spectr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  40-51     Citation Subset:  IM    
Department of Psychology, University of Miami, PO Box 248185, Coral Gables, FL 33124, USA.
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MeSH Terms
Adaptation, Psychological / physiology*
Arousal / physiology*
HIV Infections / immunology,  psychology*
Immunocompetence / immunology*
Life Change Events*
Social Adjustment*
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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