Document Detail

Stress induces tRNA cleavage by angiogenin in mammalian cells.
MedLine Citation:
PMID:  19114040     Owner:  NLM     Status:  MEDLINE    
tRNAs play a central role in protein translation, acting as the carrier of amino acids. By cloning microRNAs, we unexpectedly obtained some tRNA fragments generated by tRNA cleavage in the anticodon loop. These tRNA fragments are present in many cell lines and different mouse tissues. In addition, various stress conditions can induce this tRNA cleavage event in mammalian cells. More importantly, angiogenin (ANG), a member of RNase A superfamily, appears to be the nuclease which cleaves tRNAs into tRNA halves in vitro and in vivo. These results imply that angiogenin plays an important physiological role in cell stress response, except for the known function of inducing angiogenesis.
Hanjiang Fu; Junjun Feng; Qin Liu; Fang Sun; Yi Tie; Jie Zhu; Ruiyun Xing; Zhixian Sun; Xiaofei Zheng
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-12-27
Journal Detail:
Title:  FEBS letters     Volume:  583     ISSN:  1873-3468     ISO Abbreviation:  FEBS Lett.     Publication Date:  2009 Jan 
Date Detail:
Created Date:  2009-01-22     Completed Date:  2009-03-10     Revised Date:  2011-07-19    
Medline Journal Info:
Nlm Unique ID:  0155157     Medline TA:  FEBS Lett     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  437-42     Citation Subset:  IM    
Beijing Institute of Radiation Medicine, 27 Taiping Road, Beijing 100850, People's Republic of China.
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MeSH Terms
Anticodon / metabolism
Base Sequence
Cell Line
RNA, Transfer / metabolism*
Ribonuclease, Pancreatic / metabolism*
Stress, Physiological*
Reg. No./Substance:
0/Anticodon; 9014-25-9/RNA, Transfer; EC 3.1.27.-/angiogenin; EC, Pancreatic

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