Document Detail


Stress induces rapid changes in central catecholaminergic activity in Anolis carolinensis: restraint and forced physical activity.
MedLine Citation:
PMID:  16144657     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Immobilization stress and physical activity separately influence monoaminergic function. In addition, it appears that stress and locomotion reciprocally modulate neuroendocrine responses, with forced exercise ameliorating stress-induced serotonergic activity in lizards. To investigate the interaction of forced physical activity and restraint stress on central dopamine (DA), norepinephrine (NE), and epinephrine (Epi), we measured these catecholamines and their metabolites in select brain regions of stressed and exercised male Anolis carolinensis lizards. Animals were handled briefly to elicit restraint stress, with some lizards additionally forced to run on a track until exhaustion, or half that time (50% of average time to exhaustion), compared to a control group that experienced no restraint or exercise. Norepinephrine concentrations in the hippocampus and locus ceruleus decreased with restraint stress, but returned to control levels following forced exhaustion. Levels of NE in the raphé nuclei and area postrema, and epinephrine in raphé became elevated following restraint stress, and returned to control levels following forced physical activity to 50% or 100% exhaustion. Striatal DA increased as animals were exercised to 50% of exhaustion, and returned to baseline with exhaustion. At exhaustion, striatal Epi levels were diminished, compared with controls. In the area postrema, exhaustion reversed a decline in epinephrine levels that followed forced physical activity. These results suggest that stress stimulates a rapid influence on central catecholamines. In addition, forced exercise, and even exhaustion, may alleviate the effects of restraint stress on central monoamines.
Authors:
R Parrish Waters; Aaron J Emerson; Michael J Watt; Gina L Forster; John G Swallow; Cliff H Summers
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Brain research bulletin     Volume:  67     ISSN:  0361-9230     ISO Abbreviation:  Brain Res. Bull.     Publication Date:  2005 Oct 
Date Detail:
Created Date:  2005-09-07     Completed Date:  2005-12-15     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7605818     Medline TA:  Brain Res Bull     Country:  United States    
Other Details:
Languages:  eng     Pagination:  210-8     Citation Subset:  IM    
Affiliation:
Department of Biology, University of South Dakota, Vermillion, SD 57069-2390, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Brain / anatomy & histology,  metabolism*
Brain Chemistry / physiology*
Catecholamines / metabolism*
Lizards
Male
Physical Conditioning, Animal / methods
Restraint, Physical / methods
Stress, Physiological / metabolism*
Grant Support
ID/Acronym/Agency:
P20 RR15567/RR/NCRR NIH HHS; R03 MH068303/MH/NIMH NIH HHS; R03 MH068364/MH/NIMH NIH HHS
Chemical
Reg. No./Substance:
0/Catecholamines

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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