| Stress-induced visceral analgesia assessed non-invasively in rats is enhanced by prebiotic diet. | |
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MedLine Citation:
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PMID: 22294825 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIM: To investigate the influence of repeated water avoidance stress (rWAS) on the visceromotor response (VMR) to colorectal distension (CRD) and the modulation of the response by a prebiotic diet in rats using a novel surgery-free method of solid-state manometry. METHODS: Male Wistar rats fed a standard diet with or without 4% enzyme-treated rice fiber (ERF) for 5 wk were subjected to rWAS (1 h daily x 10 d) or no stress. The VMR to graded phasic CRD was assessed by intraluminal colonic pressure recording on days 0 (baseline), 1 and 10 (45 min) and 11 (24 h) after rWAS and expressed as percentage change from baseline. Cecal content of short chain fatty acids and distal colonic histology were assessed on day 11. RESULTS: WAS on day 1 reduced the VMR to CRD at 40 and 60 mmHg similarly by 28.9% ± 6.6% in both diet groups. On day 10, rWAS-induced reduction of VMR occurred only at 40 mmHg in the standard diet group (36.2% ± 17.8%) while in the ERF group VMR was lowered at 20, 40 and 60 mmHg by 64.9% ± 20.9%, 49.3% ± 11.6% and 38.9% ± 7.3% respectively. The visceral analgesia was still observed on day 11 in ERF- but not in standard diet-fed rats. By contrast the non-stressed groups (standard or ERF diet) exhibited no changes in VMR to CRD. In standard diet-fed rats, rWAS induced mild colonic histological changes that were absent in ERF-fed rats exposed to stress compared to non-stressed rats. The reduction of cecal content of isobutyrate and total butyrate, but not butyrate alone, was correlated with lower visceral pain response. Additionally, ERF diet increased rWAS-induced defecation by 26% and 75% during the first 0-15 min and last 15-60 min, respectively, compared to standard diet, and reduced rats' body weight gain by 1.3 fold independently of their stress status. CONCLUSION: These data provide the first evidence of psychological stress-related visceral analgesia in rats that was enhanced by chronic intake of ERF prebiotic. |
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Authors:
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Muriel Larauche; Agata Mulak; Pu-Qing Yuan; Osamu Kanauchi; Yvette Taché |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: World journal of gastroenterology : WJG Volume: 18 ISSN: 1007-9327 ISO Abbreviation: World J. Gastroenterol. Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-02-01 Completed Date: 2012-03-09 Revised Date: 2012-05-15 |
Medline Journal Info:
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Nlm Unique ID: 100883448 Medline TA: World J Gastroenterol Country: China |
Other Details:
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Languages: eng Pagination: 225-36 Citation Subset: IM |
Affiliation:
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VA Greater Los Angeles Healthcare System, Los Angeles, CA 90073, USA. mlarauche@mednet.ucla.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Analgesia
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methods* Animals Colon / pathology, physiopathology Defecation Diet* Dilatation, Pathologic / complications Male Manometry / methods Prebiotics* Rats Rats, Wistar Rectum / pathology, physiopathology Stress, Psychological / complications* Visceral Pain / diet therapy*, etiology* |
| Grant Support | |
ID/Acronym/Agency:
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DK-41301/DK/NIDDK NIH HHS; P50 DK-64539/DK/NIDDK NIH HHS; R01 DK-33061/DK/NIDDK NIH HHS; R01 DK033061/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Prebiotics |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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