| Stress-induced neuroinvasiveness of a neurovirulent noninvasive Sindbis virus in cold or isolation subjected mice. | |
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MedLine Citation:
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PMID: 1849216 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Effects of cold or isolation stress on brain penetration by the neurovirulent noninvasive Sindbis virus strain (SVN) were studied in mice. SVN injected intracerebrally (i.c.) causes acute encephalitis and kills adult mice but is unable to invade the brain and kill when injected intraperitoneally (i.p.). Mice inoculated i.p. with SVN were exposed to cold stress or were singly housed. Both stress patterns induced SVN encephalitis and death in 42% (cold) and 37% (isolation) of the tested mice. No death was observed in the control injected mice. Brain virus levels were found to be more than 10(6) PFU in all dying mice. No virus was detected in the control group brains. The virus that was isolated from the brains of moribund mice demonstrated no changes in neuroinvasive and neurovirulent properties. We suggest a stress induced blood-brain-barrier opening with subsequent virus entrance as the mechanism of stress induced SVN encephalitis. |
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Authors:
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D Ben-Nathan; S Lustig; H D Danenberg |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Life sciences Volume: 48 ISSN: 0024-3205 ISO Abbreviation: Life Sci. Publication Date: 1991 |
Date Detail:
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Created Date: 1991-05-03 Completed Date: 1991-05-03 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0375521 Medline TA: Life Sci Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 1493-500 Citation Subset: IM |
Affiliation:
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Dept. of Virology, Israel Institute for Biological Research, Ness-Ziona. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Body Temperature Brain / microbiology Cold Temperature Encephalitis / etiology* Lymphatic System / pathology Mice Nervous System / microbiology* Organ Size Sindbis Virus / pathogenicity* Stress, Physiological / microbiology* Togaviridae Infections / microbiology, pathology* |
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