| Stress-induced increases in interleukin-6 and fibrinogen predict ambulatory blood pressure at 3-year follow-up. | |
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MedLine Citation:
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PMID: 15834286 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The biological mechanisms underlying the association between psychological stress and hypertension are poorly understood. Increased plasma concentrations of the inflammatory proteins interleukin-6 and fibrinogen are commonly reported both in hypertensive patients and in people subject to chronic psychological stress. Recent laboratory studies have also shown that acute psychological stress increases plasma interleukin-6 and fibrinogen concentrations in healthy individuals. OBJECTIVE: To investigate the relationship between stress-induced inflammatory responses and blood pressure using a longitudinal design. METHODS: Participants were 153 individuals from the Whitehall II cohort. Blood pressure, plasma interleukin-6 and fibrinogen were assessed in response to an acute laboratory stressor, and ambulatory blood pressure was monitored on a separate day. Three years later, a follow-up day of ambulatory blood pressure monitoring was carried out. RESULTS: Individual differences in systolic pressure, fibrinogen and interleukin-6 stress responses predicted ambulatory blood pressure at the 3-year follow-up. Larger increases in ambulatory systolic pressure over the 3-year period were predicted by larger acute fibrinogen and interleukin-6 stress responses, independently of previous ambulatory blood pressure, acute blood pressure stress responses, age, sex, body mass and smoking. CONCLUSION: Given the important roles of interleukin-6 and fibrinogen in hypertensive pathophysiology, these results indicate that psychological stress could promote hypertension through stimulating these inflammatory proteins. |
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Authors:
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Lena Brydon; Andrew Steptoe |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of hypertension Volume: 23 ISSN: 0263-6352 ISO Abbreviation: J. Hypertens. Publication Date: 2005 May |
Date Detail:
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Created Date: 2005-04-18 Completed Date: 2005-08-11 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8306882 Medline TA: J Hypertens Country: England |
Other Details:
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Languages: eng Pagination: 1001-7 Citation Subset: IM |
Affiliation:
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The Psychobiology Group, Department of Epidemiology and Public Health, University College London, UK. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Blood Pressure* Blood Pressure Monitoring, Ambulatory Body Mass Index Female Fibrinogen / analysis* Follow-Up Studies Humans Interleukin-6 / blood* Longitudinal Studies Male Middle Aged Stress, Psychological / blood* |
| Chemical | |
Reg. No./Substance:
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0/Interleukin-6; 9001-32-5/Fibrinogen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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