| Stress-induced hyperglycemia in patients with severe sepsis: a compromising factor for survival. | |
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MedLine Citation:
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PMID: 19092319 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To study the clinical and laboratory characteristics of patients with severe sepsis and baseline hyperglycemia and investigate the impact of hyperglycemia on the final outcome. PATIENTS: A total of 265 patients admitted with severe sepsis in 3 major hospitals in South-Western Greece, during a 1-year period, were included in the study. Patients were divided in 3 groups according to their glycemic profile at admission: patients with stress hyperglycemia (group SH, n=47), with diabetes mellitus (group DM, n=65), and with normal glucose level (group NG, n=153). Hyperglycemia was defined as an admission or in-hospital fasting glucose level of >or=126 mg/dL or a random blood glucose level of >or=200 mg/dL on >or=2 determinations. RESULTS: A total of 42.2% of patients with severe sepsis had baseline hyperglycemia with 17.7% having sepsis-induced stress hyperglycemia. No family history was noted in the SH group. A higher percentage of septic patients with stress hyperglycemia died compared with patients with normal glucose levels (42.5% versus 13.7%) and diabetics (42.5% versus 24.6%). Group DM had also a poorer prognosis than group NG (24.6% versus 13.7%). A positive correlation was detected between the fasting blood glucose levels of group SH and the severity of sepsis indicated by sepsis-related organ failure assessment score. CONCLUSION: Baseline hyperglycemia, including stress-induced hyperglycemia, is common in patients with severe sepsis. Stress-induced hyperglycemia is related to a more severe disease and poorer prognosis. |
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Authors:
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Leonidia Leonidou; Marina Michalaki; Ageliki Leonardou; Eftihia Polyzogopoulou; Kalliopi Fouka; Miltiadis Gerolymos; Pantelis Leonardos; Agathoklis Psirogiannis; Venetsana Kyriazopoulou; Charalambos A Gogos |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The American journal of the medical sciences Volume: 336 ISSN: 0002-9629 ISO Abbreviation: Am. J. Med. Sci. Publication Date: 2008 Dec |
Date Detail:
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Created Date: 2008-12-18 Completed Date: 2009-02-02 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0370506 Medline TA: Am J Med Sci Country: United States |
Other Details:
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Languages: eng Pagination: 467-71 Citation Subset: AIM; IM |
Affiliation:
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Department of Internal Medicine, Patras University Hospital, Rion-Patras, Greece. |
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Animals Female Humans Hyperglycemia / physiopathology* Male Middle Aged Prospective Studies Sepsis / physiopathology* Stress, Physiological* Survival Rate |
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