Document Detail

Stress-induced enhancement of fear learning: an animal model of posttraumatic stress disorder.
MedLine Citation:
PMID:  16095698     Owner:  NLM     Status:  MEDLINE    
Fear is an adaptive response that initiates defensive behavior to protect animals and humans from danger. However, anxiety disorders, such as Posttraumatic Stress Disorder (PTSD), can occur when fear is inappropriately regulated. Fear conditioning can be used to study aspects of PTSD, and we have developed a model in which pre-exposure to a stressor of repeated footshock enhances conditional fear responding to a single context-shock pairing. The experiments in this chapter address interpretations of this effect including generalization and summation or fear, inflation, and altered pain sensitivity. The results of these experiments lead to the conclusion that pre-exposure to shock sensitizes conditional fear responding to similar less intense stressors. This sensitization effect resists exposure therapy (extinction) and amnestic (NMDA antagonist) treatment. The pattern predicts why in PTSD patients, mild stressors cause reactions more appropriate for the original traumatic stressor and why new fears are so readily formed in these patients. This model can facilitate the study of neurobiological mechanisms underlying sensitization of responses observed in PTSD.
Vinuta Rau; Joseph P DeCola; Michael S Fanselow
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.     Date:  2005-08-10
Journal Detail:
Title:  Neuroscience and biobehavioral reviews     Volume:  29     ISSN:  0149-7634     ISO Abbreviation:  Neurosci Biobehav Rev     Publication Date:  2005  
Date Detail:
Created Date:  2005-10-18     Completed Date:  2005-12-15     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7806090     Medline TA:  Neurosci Biobehav Rev     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1207-23     Citation Subset:  IM    
Department of Psychology, University of California, Los Angeles, 415 Hilgard Ave, Los Angeles, CA 90095-1563, USA.
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MeSH Terms
2-Amino-5-phosphonovalerate / pharmacology
Analysis of Variance
Avoidance Learning / drug effects,  physiology*
Behavior, Animal
Conditioning (Psychology) / drug effects,  physiology
Disease Models, Animal*
Electroshock / adverse effects
Excitatory Amino Acid Antagonists / pharmacology
Extinction, Psychological / drug effects,  physiology
Freezing Reaction, Cataleptic / physiology,  radiation effects
Injections, Intraventricular / methods
Random Allocation
Rats, Long-Evans
Stress Disorders, Post-Traumatic / physiopathology*
Time Factors
Grant Support
Reg. No./Substance:
0/Excitatory Amino Acid Antagonists; 76726-92-6/2-Amino-5-phosphonovalerate

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