| Stress-induced endocrine and immunological changes in psoriasis patients and healthy controls. A preliminary study. | |
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MedLine Citation:
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PMID: 9491439 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Clinical observations suggest that psychological stress can induce exacerbation of psoriasis. It is hypothesized that these stress effects on the course and outcome of psoriasis are caused by neuroendocrine modulation of immune functions. Therefore we investigated the cardiovascular, endocrine and immunological response to a laboratory stressor in psoriasis patients and healthy controls. METHODS: Untreated (n = 7) and PUVA-treated (n = 4) psoriatics and healthy controls (n = 7) were exposed to a brief laboratory stressor (public speaking and mental arithmetic). Heart rate and blood pressure, catecholamine, cortisol, and DHEA plasma concentration, as well as distribution of T and NK lymphocytes were analyzed before, immediately after and 1 h after stress exposure. RESULTS: Heart rate and blood pressure increased in all three groups during stress exposure with the most pronounced changes in PUVA-treated patients. Psoriasis patients displayed higher adrenaline values but diminished cortisol and DHEA plasma concentrations compared to controls. NK cell numbers (CD16+, CD56+), but not T lymphocyte subsets, increased immediately after stress exposure in untreated patients and controls. This effect was significantly diminished in PUVA-treated patients. CONCLUSIONS: The data of this pilot study indicate an enhanced stress-induced autonomic response and diminished pituitary-adrenal activity in psoriasis patients. PUVA treatment seems to interfere with the cardiovascular and NK cell response to acute psychological stress. Future studies will analyze the stress-induced neuroimmunological mechanisms in psoriatics in more detail. |
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Authors:
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G Schmid-Ott; R Jacobs; B Jäger; S Klages; J Wolf; T Werfel; A Kapp; T Schürmeyer; F Lamprecht; R E Schmidt; M Schedlowski |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Psychotherapy and psychosomatics Volume: 67 ISSN: 0033-3190 ISO Abbreviation: Psychother Psychosom Publication Date: 1998 |
Date Detail:
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Created Date: 1998-04-02 Completed Date: 1998-04-02 Revised Date: 2009-11-11 |
Medline Journal Info:
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Nlm Unique ID: 0024046 Medline TA: Psychother Psychosom Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 37-42 Citation Subset: IM |
Affiliation:
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Department of Psychosomatic Medicine, Hannover Medical School, Germany. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Blood Pressure Female Heart Rate Humans Immunity, Cellular Killer Cells, Natural Lymphocyte Subsets Male Neurosecretory Systems / physiology* PUVA Therapy* Pilot Projects Pituitary-Adrenal System / immunology* Psoriasis / immunology*, psychology*, therapy Stress, Psychological* |
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