| Stress-induced eating in rats. | |
| | |
MedLine Citation:
|
PMID: 7195655 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Mild tail pinch (TP) in rats resulted in 72% of animals displaying ingestive behavior with 20% demonstrating gnawing behavior without food ingestion and 8% demonstrating licking behavior only. The animals ate steadily over 5 min with a maximum rate occurring at 1 min (0.5 +/- 0.2 g). There was a circadian rhythm of TP-induced behavior with the peak food ingestion occurring at 24 h. A mild increase in blood glucose occurred 120 s after commencement of TP (115 +/- 4 mg/dl). Common satiety signals such as stomach distension and glucose decreased food ingestion. Parenteral administration of glucagon, cholecystokinin-octapeptide, bombesin, and thyrotropin-releasing hormone resulted in suppression of TP-induced food ingestion. Chronic TP (12 5-min TP periods/day) resulted in a fall in spontaneous food intake with the total intake remaining similar to food intake prior to the chronic TP period. We suggest that TP serves as an excellent model for eating behavior because 1) it correlates well with starvation-induced eating; 2) it precludes the necessary deprivation of food and water to adrenalectomized animals; and 3) animals subjected to TP continue chewing in the face of decreased food intake allowing one to exclude the possibility that the effects of an anorectic are secondary to nausea. |
| | |
Authors:
|
A S Levine; J E Morley |
Related Documents
:
|
8185155 - Integration of postprandial function in the proximal gastrointestinal tract. role of cc... 2510205 - Effect of intravenous nutrient infusions on food intake in rats. 8971925 - Effects of cholecystokinin octapeptide (cck-8) on food intake in adult and aged rats un... 7296335 - Factors affecting food intake in the domestic chicken: the effect of infusions of nutri... 3595485 - Teratogenic effects of the fungicide maneb on chick embryos. 3460105 - Hunger perceptions and satiety responses among normal-weight bulimics and normals to a ... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: The American journal of physiology Volume: 241 ISSN: 0002-9513 ISO Abbreviation: Am. J. Physiol. Publication Date: 1981 Jul |
Date Detail:
|
Created Date: 1981-08-27 Completed Date: 1981-08-27 Revised Date: 2004-11-17 |
Medline Journal Info:
|
Nlm Unique ID: 0370511 Medline TA: Am J Physiol Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: R72-6 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Appetite Depressants / pharmacology* Blood Glucose / metabolism Body Weight Circadian Rhythm Energy Intake Ethanol / pharmacology Feeding Behavior* / drug effects Glucose / pharmacology Hormones / pharmacology* Humans Indomethacin / pharmacology Male Peptides / pharmacology* Rats Satiety Response / drug effects Stress, Psychological / physiopathology* |
| Chemical | |
Reg. No./Substance:
|
0/Appetite Depressants; 0/Blood Glucose; 0/Hormones; 0/Peptides; 50-99-7/Glucose; 53-86-1/Indomethacin; 64-17-5/Ethanol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Methods for isolation, cannulation, and in vitro study of single microvessels.
Next Document: Modifying dog litter in urban communities.