| Stress-induced dopamine release in the neostriatum: evaluation of the role of action potentials in nigrostriatal dopamine neurons or local initiation by endogenous excitatory amino acids. | |
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MedLine Citation:
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PMID: 7901337 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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It has been hypothesized that excitatory amino acids can initiate dopamine release in neostriatum. We examined whether the increase in extracellular dopamine in neostriatum produced by acute stress reflects presynaptic initiation of dopamine release by endogenous excitatory amino acids. Thirty minutes of intermittent tail-shock stress significantly elevated extracellular concentrations of dopamine, glutamate, aspartate, and gamma-aminobutyric acid in neostriatum of freely moving rats as measured with in vivo microdialysis. Local infusion of the N-methyl-D-aspartate receptor antagonist 2-amino-5-phosphonovalerate or the non-N-methyl-D-aspartate receptor antagonist 6-cyano-7-nitroquinoxaline-2,3-dione via the dialysis probe did not attenuate the stress-induced increase in extracellular dopamine. In fact, the increase was prolonged in rats treated with specific excitatory amino acid receptor antagonists. Infusion of tetrodotoxin into medial forebrain bundle increased extracellular glutamate and aspartate in neostriatum yet reduced basal dopamine in extracellular fluid to below the limit of detection of the assay and eliminated the stress-induced increase in extracellular dopamine. These findings fail to support the hypothesis that the stress-induced increase in extracellular dopamine in neostriatum is initiated locally by excitatory amino acids. Rather, the effects of stress on extracellular dopamine seem to be determined by impulse propagation in dopamine neurons. |
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Authors:
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K A Keefe; A F Sved; M J Zigmond; E D Abercrombie |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Journal of neurochemistry Volume: 61 ISSN: 0022-3042 ISO Abbreviation: J. Neurochem. Publication Date: 1993 Nov |
Date Detail:
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Created Date: 1993-11-29 Completed Date: 1993-11-29 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 2985190R Medline TA: J Neurochem Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1943-52 Citation Subset: IM |
Affiliation:
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Department of Behavioral Neuroscience, University of Pittsburgh, Pennsylvania. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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2-Amino-5-phosphonovalerate
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pharmacology* 3,4-Dihydroxyphenylacetic Acid / metabolism 6-Cyano-7-nitroquinoxaline-2,3-dione Action Potentials / drug effects, physiology* Animals Corpus Striatum / drug effects, physiology*, physiopathology Dopamine / metabolism* Electroshock Homovanillic Acid / metabolism Kainic Acid / pharmacology* Male N-Methylaspartate / pharmacology Neostriatum / drug effects, physiology*, physiopathology Neurons / drug effects, physiology* Quinoxalines / pharmacology* Rats Rats, Sprague-Dawley Stress, Psychological / physiopathology* Substantia Nigra / drug effects, physiology*, physiopathology Tetrodotoxin / pharmacology |
| Grant Support | |
ID/Acronym/Agency:
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MH09972/MH/NIMH NIH HHS; MH43947/MH/NIMH NIH HHS; MH45156/MH/NIMH NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Quinoxalines; 102-32-9/3,4-Dihydroxyphenylacetic Acid; 115066-14-3/6-Cyano-7-nitroquinoxaline-2,3-dione; 306-08-1/Homovanillic Acid; 4368-28-9/Tetrodotoxin; 487-79-6/Kainic Acid; 6384-92-5/N-Methylaspartate; 76726-92-6/2-Amino-5-phosphonovalerate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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