Document Detail


Stress-induced changes in skin barrier function in healthy women.
MedLine Citation:
PMID:  11511309     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Despite clear exacerbation of several skin disorders by stress, the effect of psychologic or exertional stress on human skin has not been well studied. We investigated the effect of three different stressors, psychologic interview stress, sleep deprivation, and exercise, on several dermatologic measures: transepidermal water loss, recovery of skin barrier function after tape stripping, and stratum corneum water content (skin conductance). We simultaneously measured the effects of stress on plasma levels of several stress-response hormones and cytokines, natural killer cell activity, and absolute numbers of peripheral blood leukocytes. Twenty-five women participated in a laboratory psychologic interview stress, 11 women participated in one night of sleep deprivation, and 10 women participated in a 3 d exercise protocol. The interview stress caused a delay in the recovery of skin barrier function, as well as increases in plasma cortisol, norepinephrine, interleukin-1beta and interleukin-10, tumor necrosis factor-alpha, and an increase in circulating natural killer cell activity and natural killer cell number. Sleep deprivation also decreased skin barrier function recovery and increased plasma interleukin-1beta, tumor necrosis factor-alpha, and natural killer cell activity. The exercise stress did not affect skin barrier function recovery, but caused an increase in natural killer cell activity and circulating numbers of both cytolytic T lymphocytes and helper T cells. In addition, cytokine responses to the interview stress were inversely correlated with changes in barrier function recovery. These results suggest that acute psychosocial and sleep deprivation stress disrupts skin barrier function homeostasis in women, and that this disruption may be related to stress-induced changes in cytokine secretion.
Authors:
M Altemus; B Rao; F S Dhabhar; W Ding; R D Granstein
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of investigative dermatology     Volume:  117     ISSN:  0022-202X     ISO Abbreviation:  J. Invest. Dermatol.     Publication Date:  2001 Aug 
Date Detail:
Created Date:  2001-08-20     Completed Date:  2001-09-20     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0426720     Medline TA:  J Invest Dermatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  309-17     Citation Subset:  IM    
Affiliation:
Department of Psychiatry, Weill Medical College, Cornell University, New York, New York 10021, USA. maltemus@mail.med.cornell.edu
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adrenocorticotropic Hormone / blood
Adult
Epinephrine / blood
Exercise
Female
Humans
Hydrocortisone / blood
Interleukin-1 / blood
Interleukin-10 / blood
Interviews as Topic
Killer Cells, Natural / cytology,  immunology
Norepinephrine / blood
Skin Physiological Phenomena / immunology*
Sleep Deprivation / immunology,  physiopathology
Stress, Psychological / immunology*,  physiopathology*
Tumor Necrosis Factor-alpha / metabolism
beta-Endorphin / blood
Chemical
Reg. No./Substance:
0/Interleukin-1; 0/Tumor Necrosis Factor-alpha; 130068-27-8/Interleukin-10; 50-23-7/Hydrocortisone; 51-41-2/Norepinephrine; 51-43-4/Epinephrine; 60617-12-1/beta-Endorphin; 9002-60-2/Adrenocorticotropic Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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