| Stress-induced behaviour in juvenile rats: effects of neonatal asphyxia, body temperature and chelation of iron. | |
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MedLine Citation:
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PMID: 15313019 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Newborn mammals, showing reduced normal body temperature, might be protected against iron-mediated, delayed neurotoxicity of perinatal asphyxia. Therefore, we investigated the effects of (1) neonatal body temperature and neonatal critical anoxia as well as (2) postanoxic chelation of iron with deferoxamine, on open-field stress-induced behaviour in juvenile rats. The third aim of this study was to compare (after the above-mentioned treatments) circadian changes in spontaneous motor activity and body temperature in juvenile rats permanently protected from any stress. Neonatal anoxia at body temperature adjusted (both during anoxia and 2 h reoxygenation) to a level typical of healthy (37 degrees C) or febrile (39 degrees C) adults led to the stress-induced hyperactivity in juvenile (5-45 days old) rats. Both normal neonatal body temperature of 33 degrees C and chelation of iron prevented the hyperactivity in rats. Neither neonatal body temperature nor neonatal anoxia affected spontaneous motor activity or body temperature of juvenile rats, recorded in their home-cages with implantable transmitters. Circadian rhythmicity was also undisturbed. Presented data support the hypothesis that physiologically reduced neonatal body temperature can provide a protection against iron-mediated postanoxic disturbances of behavioural stress responses in juvenile rats. |
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Authors:
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Justyna Rogalska; Michał Caputa; Katarzyna Wentowska; Anna Nowakowska |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Behavioural brain research Volume: 154 ISSN: 0166-4328 ISO Abbreviation: Behav. Brain Res. Publication Date: 2004 Oct |
Date Detail:
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Created Date: 2004-08-17 Completed Date: 2004-11-01 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 8004872 Medline TA: Behav Brain Res Country: Netherlands |
Other Details:
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Languages: eng Pagination: 321-9 Citation Subset: IM |
Affiliation:
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Department of Animal Physiology, Institute of General and Molecular Biology, N. Copernicus University, ul. Gagarina 9, 87-100 Toruń, Poland. rogal@biol.uni.torun.pl |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Analysis of Variance Animals Animals, Newborn Asphyxia / etiology* Behavior, Animal Body Temperature / physiology* Deferoxamine / pharmacology Exploratory Behavior / drug effects, physiology Iron / metabolism* Iron Chelating Agents / pharmacology Motor Activity / drug effects, physiology* Rats Rats, Wistar Stress, Physiological / metabolism, physiopathology* Telemetry / instrumentation Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Iron Chelating Agents; 70-51-9/Deferoxamine; 7439-89-6/Iron |
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