Document Detail

Stress increases endogenous benzodiazepine receptor ligand-monoamine oxidase inhibitory activity (tribulin) in rat tissues.
MedLine Citation:
PMID:  2830363     Owner:  NLM     Status:  MEDLINE    
The presence of both MAO and benzodiazepine (BZ) receptor binding inhibitory activities in rat tissues has been reported previously. The two activities were similarly and unevenly distributed in the tissues. This dual inhibitory activity has been termed tribulin. We report here the effect of 1 1/2 hrs cold restraint stress on tribulin activity in rat tissues together with biochemical evidence to support the concept of a physiological role of tribulin. Stress induced a significant increment of both activities in heart and kidney while no significant changes were observed in the other tissues studied. Hearts and kidneys from stressed rats also showed a significant decrease of MAO activity, a significant increase of dopamine content and a significant decrease of the binding of 3H-Ro 5-4864 to peripheral BZ receptors. Scatchard analysis of the saturation curves carried out using 3H-Ro 5-4864 (0.4-10 nM) showed significant Bmax decreases in both organs. No significant change in either of these inhibitory activities was observed in the other tissues studied. These data provide support for a role of tribulin in the biochemical response to stress.
I Armando; G Levin; M Barontini
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of neural transmission     Volume:  71     ISSN:  -     ISO Abbreviation:  J. Neural Transm.     Publication Date:  1988  
Date Detail:
Created Date:  1988-03-28     Completed Date:  1988-03-28     Revised Date:  2014-06-03    
Medline Journal Info:
Nlm Unique ID:  0337042     Medline TA:  J Neural Transm     Country:  AUSTRIA    
Other Details:
Languages:  eng     Pagination:  29-37     Citation Subset:  IM; S    
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MeSH Terms
Benzodiazepinones / metabolism
Catecholamines / metabolism
Flunitrazepam / metabolism
Kidney / metabolism*
Monoamine Oxidase / metabolism*
Monoamine Oxidase Inhibitors / metabolism*
Myocardium / metabolism*
Rats, Inbred Strains
Receptors, GABA-A / metabolism*
Restraint, Physical
Stress, Physiological / metabolism*
Reg. No./Substance:
0/Benzodiazepinones; 0/Catecholamines; 0/Monoamine Oxidase Inhibitors; 0/Receptors, GABA-A; 14439-61-3/4'-chlorodiazepam; 620X0222FQ/Flunitrazepam; 82X95S7M06/Isatin; 84788-92-1/tribulin; EC Oxidase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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